Results 91 to 100 of about 1,392,762 (281)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
DiffRayFlow: A Differentiable Freeform Optical Design Engine Based on Discrete Optimal Transport
PhotonicsFreeform surfaces play a critical role in complex light-field modulation. However, traditional geometric mapping and standard optimization methods are limited by computational cost and convergence instability in large-scale ray tracing and complex ...
Liang Wang +4 more
doaj +1 more source
Diffeomorphic density matching by optimal information transport
, 2015 We address the following problem: given two smooth densities on a manifold, find an optimal diffeomorphism that transforms one density into the other.
Bauer, Martin +2 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
MathematicsIdentifying critical infrastructure in transportation networks requires metrics that can capture both the topological structure and how demand is redistributed during disruptions.
Iman Seyedi +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
A Survey on Optimal Transport for Machine Learning: Theory and Applications
IEEE AccessOptimal Transport (OT) theory has seen increasing attention from the computer science community due to its potency and relevance in modeling and machine learning (ML).
Luiz Manella Pereira, M. Hadi Amini
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
SIDDA: SInkhorn Dynamic Domain Adaptation for image classification with equivariant neural networks
Machine Learning: Science and TechnologyModern neural networks (NNs) often do not generalize well in the presence of a ‘covariate shift’; that is, in situations where the training and test data distributions differ, but the conditional distribution of classification labels given the data ...
Sneh Pandya +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source