Results 81 to 90 of about 90,500 (318)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
, 2005 The object of the present work is the analysis of the convergence behaviour of a learning algorithm for grammars belonging to a special version -- the maximum entropy version -- of stochastic Optimality Theory.
Fischer, Markus
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Optimizing Bayesian optimization
, 2018 We are concerned primarily with improving the practical applicability of Bayesian optimization. We make contributions in three key areas. We develop an intuitive online stopping criterion, allowing only as many steps as necessary to achieve the desired target to be taken. By combining this with intelligent online switching between acquisition functions
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
An Optimality Theoretic Approach to Navajo Prefixal Syllables
, 1998 An Optimality Theoretic Approach to Navajo Prefixal Syllables Amy V. Fountain University of Arizona Navajo is a Southern Athapaskan language spoken by approximately 160,000 people in Arizona and New Mexico.
Fountain, Amy Velita
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
When is Assortment Optimization Optimal?
Proceedings of the 23rd ACM Conference on Economics and Computation, 2022 Assortment optimization concerns the problem of selling items with fixed prices to a buyer who will purchase at most one. Typically, retailers select a subset of items, corresponding to an “assortment” of brands to carry, and make each selected item available for purchase at its brand-recommended price.
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Optimizing Optimizers: Regret-optimal gradient descent algorithms
CoRR, 2020 Proceedings of Thirty Fourth Conference on Learning ...
Philippe Casgrain, Anastasis Kratsios
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On optimality in intergenerational risk sharing [PDF]
This paper defines and studies optimality in a dynamic stochastic economy with finitely lived agents, and investigates the optimality properties of an equilibrium with or without sequentially complete markets.
Gabrielle Demange
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