Results 131 to 140 of about 32,948 (308)
Necessary optimality conditions for fractional action-like problems with intrinsic and observer times [PDF]
, 2008 We prove higher-order Euler-Lagrange and DuBois-Reymond stationary conditions to fractional action-like variational problems.
Frederico, G.S.F., Torres, D.F.M.
core +1 more source
Second-Order Optimality Conditions in Locally Lipschitz Inequality-Constrained Multiobjective Optimization. [PDF]
J Optim Theory Appl, 2020 Constantin E.
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
ε-MAXIMUM PRINCIPLE IN LINEAR PROBLEM OF HYBRID SYSTEM OPTIMUM CONTROL
Наука и техника, 2009 The paper reveals necessary and sufficient conditions of optimality and sub-optimality of the programs for a hybrid system in the class of discrete control actions. The conditions are formulated in the support terms of the initial problem.
O. R. Gabasova
doaj
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Measuring Tax Efficiency: A Tax Optimality Index [PDF]
This paper introduces an index of tax optimality that measures the distance of a current tax structure from the optimal tax structure in the presence of public goods.
Pascalis Raimondos-Møller +1 more
core
Decrease Functions and Optimality Conditions [PDF]
, 2007 We give necessary, and sufficient, conditions for optimality in nonlinear programming, in terms of suitable decrease functions of the objective and constraint ...
Adi Ben-israel, Fuan Zhao
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On alternative theorems and necessary conditions for efficiency [PDF]
In this paper, we establish theorems of the alternative for a system described by inequalities, equalities and an inclusion, which are generalizations of Tucker's classical theorem of the alternative, and develop Kuhn-Tucker necessary conditions for ...
Do Van Luu, Manh-Hung Nguyen
core