Results 131 to 140 of about 7,727,198 (309)

ε-MAXIMUM PRINCIPLE IN LINEAR PROBLEM OF HYBRID SYSTEM OPTIMUM CONTROL

open access: yesНаука и техника, 2009
The paper reveals necessary and sufficient conditions of optimality and sub-optimality of the programs for a hybrid system in the class of discrete control actions. The conditions are formulated in the support terms of  the initial problem.
O. R. Gabasova
doaj  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

mic Efficiency and Pareto Optimality in a Stochastic OLG Model with Production and Social Security [PDF]

open access: yes
We analyze the interaction between risk sharing and capital accumulation in a stochastic OLG model with production. We give a complete characterization of interim Pareto optimality.
Marcus Hagedorn   +2 more
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Autosegmental spreading in optimality theory

open access: yes, 2011
This paper is a shorter version of ROA-1009 'Harmony in harmonic serialism'. Some material is omitted, but the overall presentation is probably clearer.The publisher of the book in which this excerpt appears does not permit the archiving of this or any ...

core  

Generalized Derivatives and Optimality Conditions in Nonconvex Optimization

open access: yesBulletin of the Malaysian Mathematical Sciences Society
AbstractIn this paper, we study the radial epiderivative notion for nonconvex functions, which extends the (classical) directional derivative concept. The paper presents new definition and new properties for this notion and establishes relationships between the radial epiderivative, the Clarke’s directional derivative, the Rockafellar’s subderivative ...
Gulcin Dinc Yalcin, Refail Kasimbeyli
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

On alternative theorems and necessary conditions for efficiency [PDF]

open access: yes
In this paper, we establish theorems of the alternative for a system described by inequalities, equalities and an inclusion, which are generalizations of Tucker's classical theorem of the alternative, and develop Kuhn-Tucker necessary conditions for ...
Do Van Luu, Manh-Hung Nguyen
core  

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