Results 121 to 130 of about 32,948 (308)
On a Method for Finding Extremal Controls in Systems with Constraints
Известия Иркутского государственного университета: Серия "Математика", 2019 In the class of controlled systems with constraints, the conditions for improving and optimality of control are constructed and analyzed in the form of fixed point problems.
A.S. Buldaev, I. D. Burlakov
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
On constrained set-valued optimization [PDF]
The set-valued optimization problem minC F(x), G(x)\(-K) 6= ; is considered, where F : Rn Rm and G : Rn Rp are set-valued functions, and C Rm and K Rp are closed convex cones.
Rocca Matteo, Ginchev Ivan
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Average Relaxations of Extremal Problems [PDF]
In this paper extremal problems that include averaging operation in constraints and objective are considered. The relaxation caused by a replacement of a problem without averaging with a problem that includes averaging is formally defined and ...
Anatoliy M. Tsirlin, Valdimir Kazakov
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Necessary Optimality Conditions for Nonsmooth Minimax Problems [PDF]
, 1992 Under a suitable assumption necessary optimality conditions are derived for nonsmooth minimax problems involving infinitely many functions. The results obtained here generalize some necessary optimality conditions for mathematical programming and minimax
Luu, Do Van, Oettli, Werner
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
ON NECESSARY CONDITIONS FOR EFFICIENCY IN DIRECTIONALLY DIFFERENTIABLE OPTIMIZATION PROBLEMS [PDF]
This paper deals with multiobjective programming problems with in- equality, equality and set constraints involving Dini or Hadamard differentiable func- tions.
Do Van Luu, Manh-Hung Nguyen
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