Results 141 to 150 of about 7,727,198 (309)
Necessary Optimality Conditions for Nonsmooth Minimax Problems [PDF]
, 1992 Under a suitable assumption necessary optimality conditions are derived for nonsmooth minimax problems involving infinitely many functions. The results obtained here generalize some necessary optimality conditions for mathematical programming and minimax
Luu, Do Van, Oettli, Werner
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Non-computable functions in Optimality Theory
, 1999 Is Optimality Theory a constraining theory? A formal analysis shows that it is, if two auxiliary assumptions are made: (1) that only markedness and faithfulness constraints are allowed, and (2) that input and output representations are made from the same
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Two approaches toward constrained vector optimization and identity of the solutions [PDF]
In this paper we deal with a Fritz John type constrained vector optimization problem. In spite that there are many concepts of solutions for an unconstrained vector optimization problem, we show the possibility “to double” the number of concepts when a ...
Rocca Matteo +2 more
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Second-order optimality conditions for nonlinear programs and mathematical programs. [PDF]
J Inequal Appl, 2017 Daidai I.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Some optimality principles of sentence pronunciation
, 1998 This is a compilation of handouts from 5 classes, Fall 1994, MIT, in which the proposal is advanced that the output of syntax feeds a system that determines how syntactic units are pronounced -- for example, optional and obligatory patterns of deletion ...
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Necessary optimality conditions for fractional action-like problems with intrinsic and observer times [PDF]
, 2008 We prove higher-order Euler-Lagrange and DuBois-Reymond stationary conditions to fractional action-like variational problems.
Frederico, G.S.F., Torres, D.F.M.
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