Results 41 to 50 of about 5,463,307 (266)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Glide Formation in Kalhori Dialect [PDF]
̒Ilm-i Zabān, 2014 In this paper, the aim is to analyze and describe the process of glide formation in Kurdish (Kalhori dialect) using optimality theory of concurrency approach.
Ebrahim Badakhshan, Mohammad Zamani
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Optimality Theory: Constraint Interaction in Generative Grammar
, 2002 This work develops a conception of grammar in which optimality with respect to a set of constraints defines well-formedness. The argument begins with a brief assessment of the promise of optimization-based approaches, focusing on issues of explanation ...
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Constraint summation in phonological theory
Journal of Language Modelling, 2021 The classical constraints used in phonological theory apply to a single candidate at a time. Yet, some proposals in the phonological literature have enriched the classical constraint toolkit with constraints that instead apply to multiple candidates ...
Giorgio Magri, Benjamin Storme
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Computing Optimal Forms in Optimality Theory: Basic Syllabification
, 1995 In Optimality Theory, grammaticality is defined in terms of optimization over a large (often infinite) space of candidates. This raises the question of how grammatical forms might be computed.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2005 The object of the present work is the analysis of the convergence behaviour of a learning algorithm for grammars belonging to a special version -- the maximum entropy version -- of stochastic Optimality Theory.
Fischer, Markus
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