Results 51 to 60 of about 11,404 (263)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating Sonority Sequencing Principle in One Syllable CVCC Persian Words in Gnanadesikan’s Ternary Scales [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2016 The study aims to investigate Sonority Sequencing Principle(SSP) in final consonant cluster in one syllable Persian words in the frame work of “three dimensions sonority model” proposed by Gnanadesican (1997).
Mehrzad mansouri
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Analysis of Reduplication Process in Delfan Laki Dialect: Optimality Theory [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2017 The present research seeks to study the reduplication processes in Delfan Laki dialect. To fulfill this objective, the dialectal data has been collected via recording ten hours of native's speeches (five males & five females aged between 20 and 60 years ...
Farzane Heidari
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
PARETO-OPTIMALITY AND L-OPTIMAL FOR SOLVING SOME CLASSES OF OPTIMAL CONTROL PROBLEM
Финансы: теория и практика, 2017 Many practical problems of economic activities and a number of important issues of economic theory are connected to the choice of optimal solution. An adequate economic theory should reflect the process of continuous development of the economic system ...
V. V. Kiselev
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Schwa in Contemporary Standard Russian
Poljarnyj Vestnik: Norwegian Journal of Slavic Studies, 2000 This article explores a number of generalizations regarding the distribution of schwa in Russian and outlines an analysis in terms of Optimality Theory.
Tore Nesset
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source