Results 51 to 60 of about 5,463,307 (266)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Linguistics, 2023 We consider two asymmetries reported in the literature on word prosodic systems: the tendency to allow more prosodic contrast in nouns than in verbs and the tendency to avoid stress on functional material.
Simonović Marko, Kager René
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Optimality theory and assessment of developing and disordered phonologies
Journal of Indian Speech Language & Hearing Association, 2015 Optimality theory (OT) is a comparatively recent linguistic theory which has been introduced in the early 1990s. OT's description of children's error patterns as patterns that are derived from a hierarchy of conflicting universal constraints has much ...
Froogh Shooshtaryzadeh
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Investigating Sonority Sequencing Principle in One Syllable CVCC Persian Words in Gnanadesikan’s Ternary Scales [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2016 The study aims to investigate Sonority Sequencing Principle(SSP) in final consonant cluster in one syllable Persian words in the frame work of “three dimensions sonority model” proposed by Gnanadesican (1997).
Mehrzad mansouri
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Analysis of Reduplication Process in Delfan Laki Dialect: Optimality Theory [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2017 The present research seeks to study the reduplication processes in Delfan Laki dialect. To fulfill this objective, the dialectal data has been collected via recording ten hours of native's speeches (five males & five females aged between 20 and 60 years ...
Farzane Heidari
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Coordination in Optimality Theory
, 2005 This dissertation provides an analysis of coordination within a restricted version of Optimality Theory (OT), operating exclusively with alignment and faithfulness constraints.
Gáspár, Miklós
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Prosodic domains and ambisyllabicity in optimality theory
, 1997 Selkirk 1984, 1986, Nespor & Vogel 1986 and others independently argue that PrWd structure is built from morphological structure. In Optimality Theory, Generalized Alignment (McCarthy & Prince 1993b) has been successful in encoding the close relationship
Hong, Soonhyun
core +1 more source