Results 81 to 90 of about 933,480 (358)

Methylomic Biomarkers of Lithium Response in Bipolar Disorder: A Proof of Transferability Study

Pharmaceuticals, 2022
Response to lithium (Li) is highly variable in bipolar disorders (BD) and no clinical or biological predictors of long-term response have been validated to date.
Cynthia Marie-Claire, Cindie Courtin, Frank Bellivier, Jan Scott, Bruno Etain   +4 more
doaj   +1 more source

Digital Ecosystems: Ecosystem-Oriented Architectures

, 2011
We view Digital Ecosystems to be the digital counterparts of biological ecosystems. Here, we are concerned with the creation of these Digital Ecosystems, exploiting the self-organising properties of biological ecosystems to evolve high-level software ...
Briscoe, Gerard, De Wilde, Philippe, Sadedin, Suzanne   +2 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood–Brain Barrier Reveals Interspecies Differences

Frontiers in Cell and Developmental Biology, 2020
Transient receptor potential vanilloid 1-4 (TRPV1-4) expression and functionality were investigated in brain microvessel endothelial cells (BMEC) forming the blood–brain barrier (BBB) from rat and human origins.
Huilong Luo, Huilong Luo, Bruno Saubamea, Stéphanie Chasseigneaux, Véronique Cochois, Maria Smirnova, Fabienne Glacial, Nicolas Perrière, Catarina Chaves, Salvatore Cisternino, Salvatore Cisternino, Xavier Declèves, Xavier Declèves   +12 more
doaj   +1 more source

Integrated system to perform surrogate based aerodynamic optimisation for high-lift airfoil [PDF]

, 2016
This work deals with the aerodynamics optimisation of a generic two-dimensional three element high-lift configuration. Although the high-lift system is applied only during take-off and landing in the low speed phase of the flight the cost efficiency of ...
Cross, M., Di Pasquale, Davide, Kipouros, Timoleon, Savill, Mark A., Zhu, F.   +4 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Shorter Total Length of Stay After Intraperitoneal Fosfomycin, Metronidazole, and Molgramostim for Complicated Appendicitis: A Pivotal Quasi-Randomized Controlled Trial

Frontiers in Surgery, 2020
Background: We aimed to investigate the difference in the total length of hospital stay (LOS) after intraperitoneal vs. intravenous antibiotic treatment in patients with complicated appendicitis.Methods: We conducted a quasi-randomized prospective ...
Siv Fonnes, Søren Roepstorff, Barbara Juliane Holzknecht, Christoffer Skov Olesen, Joachim Hjalde Halmsted Olsen, Line Schmidt, Rasmus Alder, Sara Gamborg, Tilde Rasmussen, Magnus Arpi, Lars Nannestad Jørgensen, Jacob Rosenberg   +11 more
doaj   +1 more source

Direct Step & Shoot: a New Module for Prostate Cancer IMRT [PDF]

, 2007
Aims & Objectives The aim of this treatment planning study is to compare the techniques of 3D conformal radiotherapy (3DCRT) and IMRT to determine the feasible advantages for prostate cancer patientsof using a new direct step & shoot (DSS) IMRT module.
Bogner, Ludwig, Hipp, Matthias, Treutwein, Marius   +2 more
core  

Heterogeneous Batch Distillation Processes: Real System Optimisation [PDF]

, 2008
In this paper, optimisation of batch distillation processes is considered. It deals with real systems with rigorous simulation of the processes through the resolution full MESH differential algebraic equations. Specific software architecture is developed,
B. Kotai, Bernot, Bernot, Betlem, Bonny, Bonny, Coward, Farhat, Farhat, Fernhloz, Fraga, Fraga, Frey, Furlonge, Gmehling, Hanke, Jang, Kao, Kim, Kiva, Lang, Lelkes, Modla, Mukherjee, Mutjaba, Noda, Novak, O. Baudouin, P. Floquet, P. Lang, Rodriguez-Donis, Rodriguez-Donis, Rodríguez-Donis, S. Massebeuf, S. Pommier, Skouras, Skouras, Sorensen, Spellucci, Spellucci, V. Gerbaud, Van Dongen   +41 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source