Results 91 to 100 of about 9,308,983 (309)

Progressive construction of a parametric reduced-order model for PDE-constrained optimization [PDF]

open access: yes, 2014
An adaptive approach to using reduced-order models as surrogates in PDE-constrained optimization is introduced that breaks the traditional offline-online framework of model order reduction.
Farhat, Charbel, Zahr, Matthew J.
core  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

A Powerful Optimization Tool for Analog Integrated Circuits Design [PDF]

open access: yes, 2013
This paper presents a new optimization tool for analog circuit design. Proposed tool is based on the robust version of the differential evolution optimization method. Corners of technology, temperature, voltage and current supplies are taken into account
Jakovenko, J., Kubar, M.
core   +1 more source

Model Guided Sampling Optimization for Low-dimensional Problems

open access: yes, 2015
Optimization of very expensive black-box functions requires utilization of maximum information gathered by the process of optimization. Model Guided Sampling Optimization (MGSO) forms a more robust alternative to Jones' Gaussian-process-based EGO ...
Bajer, Lukas, Holena, Martin
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Probabilistic Model for Aero-Engines Fleet Condition Monitoring

open access: yesAerospace, 2020
Since aeronautic transportation is responsible for a rising share of polluting emissions, it is of primary importance to minimize the fuel consumption any time during operations.
Valentina Zaccaria   +3 more
doaj   +1 more source

Evolutionary Algorithms for [PDF]

open access: yes
Many real-world problems involve two types of problem difficulty: i) multiple, conflicting objectives and ii) a highly complex search space. On the one hand, instead of a single optimal solution competing goals give rise to a set of compromise solutions,
Eckart Zitzler   +3 more
core  

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren   +16 more
wiley   +1 more source

Towards a Theory-Guided Benchmarking Suite for Discrete Black-Box Optimization Heuristics: Profiling $(1+\lambda)$ EA Variants on OneMax and LeadingOnes

open access: yes, 2018
Theoretical and empirical research on evolutionary computation methods complement each other by providing two fundamentally different approaches towards a better understanding of black-box optimization heuristics.
Badkobeh Golnaz   +5 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

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