Results 151 to 160 of about 5,593,327 (347)
A Comparison of Several Current Optimization Methods, and the use of Transformations in Constrained Problems [PDF]
, 1966 M. J. Box
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Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Strong Metric Subregularity of the optimality mapping and second-order sufficient optimality conditions in extremal problems with constraints [PDF]
arXivThis is a review paper, summarizing without proofs recent results by the authors on the property of strong metric subregularity (SMSR) in optimization. It presents sufficient conditions for SMSR of the optimality mapping associated with a set of necessary optimality conditions in three types of constrained optimization problems: mathematical ...
arxiv
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Multi-Objective Optimization Technique Based on QUBO and an Ising Machine
IEEE AccessWith an increase in the complexity of society, solving multi-objective optimization problems (MOPs) has become crucial. In this study, we introduced a novel method called “quadratic unconstrained binary optimization based on the weighted normal ...
Hiroshi Ikeda, Takashi Yamazaki
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Optimization in Control Theory and Practice [PDF]
, 1969 I. Gumowski, C. Mira, A. E. Pearson
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
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Trajectory optimization using regularized variables. [PDF]
, 1969 B. D. Tapley +2 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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, 2011 AbstractEmbedded systems have to be efficient (at least) with respect to the objectives considered in this book. In particular, this applies to resource-constrained mobile systems, including sensor networks embedded in the Internet of Things. In order to achieve this goal, many optimizations have been developed.
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