Results 41 to 50 of about 4,124,575 (251)

Extra intravenous Ustekinumab reinduction is an effective optimization strategy for patients with refractory Crohn’s disease

Frontiers in Medicine, 2023
ObjectivesUstekinumab (UST) optimization strategies, including shortening intervals and intravenous reinduction, should be administered to patients with partial or loss of respond. Evidence comparing these types of optimization treatments is limited.
Jiayin Yao, Jiayin Yao, Xiang Peng, Xiang Peng, Yingkui Zhong, Yingkui Zhong, Tao Su, Tao Su, Adam Bihi, Adam Bihi, Junzhang Zhao, Junzhang Zhao, Tao Liu, Tao Liu, Wei Wang, Wei Wang, Pinjin Hu, Pinjin Hu, Min Zhang, Min Zhang, Min Zhi, Min Zhi   +21 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Handbook of Moth-Flame Optimization Algorithm

, 2022
Moth-Flame Optimization algorithm is an emerging meta-heuristic and has been widely used in both science and industry. Solving optimization problem using this algorithm requires addressing a number of challenges, including multiple objectives ...
Mirjalili, S, Seyedali Mirjalili
core   +1 more source

Hippopotamus optimization algorithm: a novel nature-inspired optimization algorithm

Scientific Reports
The novelty of this article lies in introducing a novel stochastic technique named the Hippopotamus Optimization (HO) algorithm. The HO is conceived by drawing inspiration from the inherent behaviors observed in hippopotamuses, showcasing an innovative ...
Mohammad Hussein Amiri, Nastaran Mehrabi Hashjin, Mohsen Montazeri, Seyedali Mirjalili, Nima Khodadadi   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A memetic ant colony optimization algorithm for the dynamic travelling salesman problem [PDF]

, 2010
Copyright @ Springer-Verlag 2010.Ant colony optimization (ACO) has been successfully applied for combinatorial optimization problems, e.g., the travelling salesman problem (TSP), under stationary environments.
Yang, S, Shengxiang Yang, Mavrovouniotis, M, Michalis Mavrovouniotis, Yang, Shengxiang, Mavrovouniotis, Michalis   +5 more
core   +1 more source

Raccoon Optimization Algorithm

IEEE Access, 2019
Population-based meta-heuristic is a high-level method intended to provide sufficient solution for problems with incomplete information among a massive volume of solutions. However, it does not guarantee to attain global optimum in a reasonable time.
Sina Zangbari Koohi, Nor Asilah Wati Abdul Hamid, Mohamed Othman, Gafurjan Ibragimov   +3 more
doaj   +1 more source