Results 61 to 70 of about 1,195,901 (281)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Development of initial optimization and transmission matrix calculation algorithms. New concepts to account for refractive index variations with adaptive meshing, Levy statistics and Monte Carlo modelling of light propagation in complex ...
Benoit Liquet +2 more
+6 more sources
Anti-coronavirus optimization algorithm
Soft Computing, 2022 This paper introduces a new swarm intelligence strategy, anti-coronavirus optimization (ACVO) algorithm. This algorithm is a multi-agent strategy, in which each agent is a person that tries to stay healthy and slow down the spread of COVID-19 by observing the containment protocols.
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Biomimetics, 2023 One of the most used artificial intelligence techniques for maximum power point tracking is artificial neural networks. In order to achieve successful results in maximum power point tracking, the training process of artificial neural networks is ...
Ebubekir Kaya +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Satisfiability-Based Algorithms for Boolean Optimization
, 2004 This paper proposes new algorithms for the Binate Covering Problem (BCP), a well-known restriction of Boolean Optimization. Binate Covering finds application in many areas of Computer Science and Engineering.
Manquinho, V., Marques-Silva, J. P.
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Algorithms for CVaR Optimization in MDPs [PDF]
, 2014 In many sequential decision-making problems we may want to manage risk by minimizing some measure of variability in costs in addition to minimizing a standard criterion.
Chow, Yinlam, Ghavamzadeh, Mohammad
core +2 more sources