Results 11 to 20 of about 593,062 (219)

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

Molecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li, Jing-jing Li, Ni Zhao, Ying Ma, Bin Di   +4 more
doaj   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Antioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu, Qiuyue Zhang, Yuqi Guo, Hengheng Zhang, Xiaoke Guo, Qidong You, Lei Wang   +6 more
doaj   +1 more source

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang, Yu Xia, Chunqiu Yu, Huijie Du, Jinchang Liu, Hui Li, Shihui Huang, Qihua Zhu, Yungen Xu, Yi Zou   +9 more
doaj   +1 more source

Optimization design in single wagon-wheel fuel grain of hybrid rocket motor

FirePhysChem, 2021
The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang, Cai Guobiao, Tian Hui, Zhu Hao, Zhang Yuanjun, Li Xintong   +5 more
doaj   +1 more source

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

Molecules, 2023
At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu, Sudan Sun, Qidong You, Lei Wang   +3 more
doaj   +1 more source

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Acta Pharmaceutica Sinica B, 2022
The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You, Zhengyu Jiang   +10 more
doaj   +1 more source

Multi-objective topology design optimization combined with robust optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2023
Topology optimization (TO), which is a design optimization technique that does not require design parameters, has been attracting attention. TO has a high degree of freedom and can obtain a novel design shape suitable for desired purposes.
Akito MARUO, Norihiko ITANI, Ayano HASOME, Takashi YAMAZAKI, Hajime IGARASHI   +4 more
doaj   +1 more source

High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

Advances in Aerodynamics, 2022
Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation.
Bo-Wen Zan, Zhong-Hua Han, Chen-Zhou Xu, Ming-Qi Liu, Wen-Zheng Wang   +4 more
doaj   +1 more source

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

Molecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang   +4 more
doaj   +1 more source

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

European Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He, Ke Wang, Haojie Che, Huifang Wang, Kan Yang, Guiming Zhang, Jingchun Yao, Jinxin Wang   +7 more
doaj   +1 more source