Results 41 to 50 of about 600,273 (269)
Scientific Reports, 2021 Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors.
Yu Li +5 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Recognition and Positioning of Fresh Tea Buds Using YOLOv4-lighted + ICBAM Model and RGB-D Sensing
Agriculture, 2023 To overcome the low recognition accuracy, slow speed, and difficulty in locating the picking points of tea buds, this paper is concerned with the development of a deep learning method, based on the You Only Look Once Version 4 (YOLOv4) object detection ...
Shudan Guo +7 more
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Optimality of experimental designs
Discrete Mathematics, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Recognition and Positioning of Strawberries Based on Improved YOLOv7 and RGB-D Sensing
AgricultureTo improve the speed and accuracy of the methods used for the recognition and positioning of strawberry plants, this paper is concerned with the detection of elevated-substrate strawberries and their picking points, using a strawberry picking robot ...
Yuwen Li +5 more
doaj +1 more source
Design Optimization of a Multi-Megawatt Wind Turbine Blade with the NPU-MWA Airfoil Family
Energies, 2019 A new airfoil family, called NPU-MWA (Northwestern Polytechnical University Multi-megawatt Wind-turbine A-series) airfoils, was designed to improve both aerodynamic and structural performance, with the outboard airfoils being designed at high design lift
Jianhua Xu +3 more
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Redox Biology, 2020 Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress.
Mengchen Lu +4 more
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Robustness of A-optimal designs
Linear Algebra and its Applications, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Masaro, Joe, Wong, Chi Song
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