Results 51 to 60 of about 2,303,688 (304)

A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions

open access: yesRedox Biology, 2020
Transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (Keap1), control the redox and metabolic homeostasis and oxidative stress.
Mengchen Lu   +4 more
doaj   +1 more source

PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis

open access: yesFrontiers in Immunology, 2022
ObjectiveThis study conducted a comprehensive analysis of the members of the PTPN family and emphasized the key role of PTPN2 as a potential therapeutic target and diagnostic biomarker in improving the survival rate of PAAD.MethodOncomine was used to ...
Wenbin Kuang   +15 more
doaj   +1 more source

Performance-based optimization of structures: theory and applications [PDF]

open access: yes, 2005
Performance-based Optimization of Structures introduces a method to bridge the gap between optimization theory and its practical applications to structural engineering.
Liang, Qing Quan
core  

Optimal Experimental Designs

open access: yesThe Annals of Mathematical Statistics, 1966
Abstract : This paper presents a number of results concerning the theory of the optimal design of experiments initiated and principal developed by Elfving, Kiefer and Wolfowitz. The paper contains approximately half expository and half new material. The proofs are mostly new and presented in a unified manner.
Karlin, Samuel, Studden, William J.
openaire   +2 more sources

Optimal Platform Design

open access: yesCoRR, 2014
There is some overlap between this paper and the paper "Optimal Mechanism Design and Money Burning," which appeared in the STOC 2008 conference and as arXiv:0804.2097. However, the focus of this paper is different, with some of our earlier results omitted and several new results ...
Jason D. Hartline, Tim Roughgarden
openaire   +2 more sources

Conversion Rate Optimization through Evolutionary Computation

open access: yes, 2017
Conversion optimization means designing a web interface so that as many users as possible take a desired action on it, such as register or purchase.
Brundage, Myles   +9 more
core   +1 more source

Optimal Queue Design

open access: yesProceedings of the 22nd ACM Conference on Economics and Computation, 2020
We study the optimal method for rationing scarce resources through a queue system. The designer controls agents' entry into a queue and their exit, their service priority -- or queueing discipline -- as well as their information about queue priorities, while providing them with the incentive to join the queue and, importantly, to stay in the queue ...
Yeon-Koo Che, Olivier Tercieux
openaire   +2 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Recognition and Positioning of Strawberries Based on Improved YOLOv7 and RGB-D Sensing

open access: yesAgriculture
To improve the speed and accuracy of the methods used for the recognition and positioning of strawberry plants, this paper is concerned with the detection of elevated-substrate strawberries and their picking points, using a strawberry picking robot ...
Yuwen Li   +5 more
doaj   +1 more source

Matrix-Monotonic Optimization for MIMO Systems [PDF]

open access: yes, 2014
For MIMO systems, due to the deployment of multiple antennas at both the transmitter and the receiver, the design variables e.g., precoders, equalizers, training sequences, etc. are usually matrices.
Ma, Shaodan   +2 more
core  

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