Results 31 to 40 of about 600,273 (269)

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

Nature Communications
Stimulator of Interferon Genes (STING) is a pivotal adaptor protein in the innate immune pathway, and its aberrant activation is closely associated with the pathogenesis of autoimmune diseases.
Hui Li, Wei Zheng, Wenjing Bian, Mei Li, Zhidan Fan, Ziwen Feng, Xiaoyan Liu, Shiduo Zhang, Haohao Lu, Yinquan Huang, Jiaqing Jia, Yifan Zhang, Linlin Li, Chunchen Che, Haiguo Yu, Yibei Xiao, Qidong You, Xiaoli Xu   +17 more
doaj   +1 more source

Integrated Design Optimization of Aerodynamic Shape and Flow Control Parameters for Co-Flow Jet Airfoils

Aerospace
Co-Flow Jet (CFJ) technology is an effective active flow control method for improving aerodynamic performance by enhancing circulation and suppressing flow separation.
Keying Chen, Ke Song, Zhonghua Han, Fuyang Ding, Chi Han   +4 more
doaj   +1 more source

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

European Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He, Ke Wang, Haojie Che, Huifang Wang, Kan Yang, Guiming Zhang, Jingchun Yao, Jinxin Wang   +7 more
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Flow structures and wall parameters on rotating riblet disks and their effects on drag reduction

Alexandria Engineering Journal, 2022
The demand of energy saving and loss mitigation in modern industry gives rise to drag reduction techniques such as micro groove/riblet ever since the last century.
Tong Liang, Yang Xu, Jiawen Li, Guobiao Cai   +3 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders

Molecules
Molecular glue degraders (MGDs) constitute a class of innovative therapeutic agents within the field of targeted protein degradation (TPD). In contrast to proteolysis-targeting chimeras (PROTACs), MGDs induce protein degradation by stabilizing the ...
Yifan Zhang, Linlin Li, Jiajia Xu, Chunchen Che, Jiaqing Jia, Haohao Lu, Qidong You, Xiaoli Xu   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Concise and Efficient Total Synthesis of α-Mangostin and β-Mangostin from

Natural Product Communications, 2013
The concise, efficient synthesis of α-mangostin is described in eight simple steps with 8.3% overall yield. Highlights include a practical approach to construct the isopentene groups and other diverse groups at C–2 and C–8 of the xanthene skeleton ...
Dandan Xu, Ying Nie, Xizhou Liang, Ling Ji, Songyuan Hu, Qidong You, Fan Wang, Hongchun Ye, Jinxin Wang   +8 more
doaj   +1 more source