Results 31 to 40 of about 2,303,688 (304)

A-optimal design matrices

Discrete Mathematics, 1984
The tools in search of A-optimal designs are listed and the authors derive A-optimal chemical balance weighing designs (that is, \(N\times n\) matrices with elements 1, -1 and 0) for \(N\geq 7\), \(n\leq 6\).
Chi Song Wong, Joseph C. Masaro
openaire   +1 more source

A constrained multi-objective surrogate-based optimization algorithm [PDF]

, 2014
Surrogate models or metamodels are widely used in the realm of engineering for design optimization to minimize the number of computationally expensive simulations.
Couckuyt, Ivo, Dhaene, Tom, Ferranti, Francesco, Singh, Prashant   +3 more
core   +1 more source

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

Molecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang   +4 more
doaj   +1 more source

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

European Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He, Ke Wang, Haojie Che, Huifang Wang, Kan Yang, Guiming Zhang, Jingchun Yao, Jinxin Wang   +7 more
doaj   +1 more source

Nonlinear Matroid Optimization and Experimental Design [PDF]

, 2007
We study the problem of optimizing nonlinear objective functions over matroids presented by oracles or explicitly. Such functions can be interpreted as the balancing of multi-criteria optimization. We provide a combinatorial polynomial time algorithm for
Eva Riccomagno, Fries A., Henry Wynn, Hugo Maruri-Aguilar, Jon Lee, Robert Weismantel, Shmuel Onn, Yael Berstein   +7 more
core   +7 more sources

Flow structures and wall parameters on rotating riblet disks and their effects on drag reduction

Alexandria Engineering Journal, 2022
The demand of energy saving and loss mitigation in modern industry gives rise to drag reduction techniques such as micro groove/riblet ever since the last century.
Tong Liang, Yang Xu, Jiawen Li, Guobiao Cai   +3 more
doaj   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

Scientific Reports, 2021
Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors.
Yu Li, Yuantao Wang, Wanpeng Zhang, Xinchen Wang, Lu Chen, Shuping Wang   +5 more
doaj   +1 more source

An optimization method for nacelle design [PDF]

, 2017
A multi-objective optimiZation method is demonstrated using an evolutionary genetic algorithm. The applicability of this method to preliminary nacelle design is demonstrated by coupling it with a response surface model of a wide range of nacelle designs.
Heidebrecht, A., MacManus, David G., Robinson, M.   +2 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source