Results 81 to 90 of about 19,096,786 (283)

Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties

Molecules, 2017
Pyrazino[2,1-a]isoquinolin analogues were reported as potent activators of Nrf2/ARE signaling both in vitro and in vivo by our group. In this study, we simplified the ring system to investigate the functions of various parts of the pyrazino[2,1-a ...
Hongbin Dai, Qiong Jiao, Tian Liu, Qidong You, Zhengyu Jiang   +4 more
doaj   +1 more source

Efficient Robust Optimization of Metal Forming Processes using a Sequential Metamodel Based Strategy [PDF]

, 2011
The coupling of Finite Element (FE) simulations to mathematical optimization techniques has contributed significantly to product improvements and cost reductions in the metal forming industries.
Boogaard, A.H. van den, Klaseboer, G., Wiebenga, J.H.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

Proceedings, 2019
Antibiotic resistance is one of the biggest threats to humankind [1,2]. [...]
Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch   +3 more
doaj   +1 more source

Conversion Rate Optimization through Evolutionary Computation

, 2017
Conversion optimization means designing a web interface so that as many users as possible take a desired action on it, such as register or purchase.
Brundage, Myles, Cordell, Ron, Dean, Randy, Epstein, Jonathan, Iscoe, Neil, Lamba, Gurmeet, Miikkulainen, Risto, Nazari, Sam, Schoolland, Cory, Shagrin, Aaron   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Physics-informed neural networks for solving forward and inverse Vlasov–Poisson equation via fully kinetic simulation

Machine Learning: Science and Technology, 2023
The Vlasov–Poisson equation is one of the most fundamental models in plasma physics. It has been widely used in areas such as confined plasmas in thermonuclear research and space plasmas in planetary magnetospheres.
Baiyi Zhang, Guobiao Cai, Huiyan Weng, Weizong Wang, Lihui Liu, Bijiao He   +5 more
doaj   +1 more source

Concepts and methods in optimization of integrated LC VCOs [PDF]

, 2001
Underlying physical mechanisms controlling the noise properties of oscillators are studied. This treatment shows the importance of inductance selection for oscillator noise optimization. A design strategy centered around an inductance selection scheme is
Hajimiri, Ali, Ham, Donhee
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Advanced Science
Overcoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib‐resistant cells exhibit a strong dependence on glutamine metabolism.
Jiali Huang, Xiankang Zhang, Hui Zhang, Yu Li, Huidan Huang, Zhiyu Li, Zhixia Qiu, Hongxi Wu, Dechun Huang, Xi Xu, Jinlei Bian   +10 more
doaj   +1 more source