Results 61 to 70 of about 16,482,147 (331)

Dark Forest Algorithm: A Novel Metaheuristic Algorithm for Global Optimization Problems [PDF]

, 2023
Dongyang Li, Shiyu Du, Yiming Zhang, Meiting Zhao   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Simple Case Study on Radius of Radial Basis Function Network for Sequential Approximate Optimization

SICE Journal of Control, Measurement, and System Integration, 2017
Radial basis function (RBF) networks are used for various research field. Especially, they make handling easy for classification and function approximation due to their mathematical form.
Yoshiaki Katada
doaj   +1 more source

Features of the use of specialized languages for the construction of geometric models of cellular objects in fi element modeling and optimization calculations

Системный анализ и прикладная информатика, 2019
To perform optimization calculations based on the finite element approach in accordance with the criteria accepted by the researcher, it is necessary to first create a parametric geometric model of the product so as to be able to further determine their ...
V. V. Naprasnikov, Yu. V. Polozkov, A. V. Borodulya, D. P. Kunkevich   +3 more
doaj   +1 more source

Firefly Algorithm for Cardinality Constrained Mean-Variance Portfolio Optimization Problem with Entropy Diversity Constraint

TheScientificWorldJournal, 2014
Portfolio optimization (selection) problem is an important and hard optimization problem that, with the addition of necessary realistic constraints, becomes computationally intractable.
Nebojša Bačanin, M. Tuba
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Novel Prescribed-Time Convergence Acceleration Algorithm with Time Rescaling

Mathematics
In machine learning, the processing of datasets is an unavoidable topic. One important approach to solving this problem is to design some corresponding algorithms so that they can eventually converge to the optimal solution of the optimization problem ...
Xuehui Mei, Pengrui Zhang, Haijun Jiang, Zhiyong Yu   +3 more
doaj   +1 more source

Optimal Task Allocation Algorithm Based on Queueing Theory for Future Internet Application in Mobile Edge Computing Platform

Sensors, 2022
For 5G and future Internet, in this paper, we propose a task allocation method for future Internet application to reduce the total latency in a mobile edge computing (MEC) platform with three types of servers: a dedicated MEC server, a shared MEC server,
Yukiko Katayama, Takuji Tachibana
doaj   +1 more source

Exploring Initialization Strategies for Metaheuristic Optimization: Case Study of the Set-Union Knapsack Problem [PDF]

, 2023
José García, Andrés Leiva-Araos, Broderick Crawford, Ricardo Soto, Hernán Pinto   +4 more
openalex   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source