Results 71 to 80 of about 55,356 (266)

EPPTA: Efficient partially observable reinforcement learning agent for penetration testing applications

Engineering Reports
In recent years, penetration testing (pen‐testing) has emerged as a crucial process for evaluating the security level of network infrastructures by simulating real‐world cyber‐attacks.
Zegang Li, Qian Zhang, Guangwen Yang
doaj   +1 more source

Innovative Structural Optimization and Dynamic Performance Enhancement of High-Precision Five-Axis Machine Tools

Journal of Manufacturing and Materials Processing
To satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera, Tzu-Chi Chan, Jyun-Sian Yang   +2 more
doaj   +1 more source

DYNAMIC SYSTEMS [PDF]

Fiabilitate şi Durabilitate, 2016
This article introduces concepts of dynamical systems theory such as phase space, phase space reconstruction and analysis of phase space, and their application to theanalysis of behaving agents.
Dragos Vasile VÎGA, Olimpia PECINGINA, Constantin BOGDAN   +2 more
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Optimization

Journal of Research of the National Bureau of Standards, 1985
Most research and development projects require the optimization of a system response as a function of several experimental factors. Familiar chemical examples are the maximization of product yield as a function of reaction time and temperature; the maximization of analytical sensitivity of a wet chemical method as a function of reactant concentration ...
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Profile-based optimizations for JavaScript programs

Труды Института системного программирования РАН, 2018
In recent years, JavaScript has become one of the most popular programming languages on the web. Many massive applications are written using JavaScript, such as Gmail, Google docs, etc. JavaScript is also used in the Node.js - server-side web application
V. . Vardanyan
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Constructal Optimizations for Heat and Mass Transfers Based on the Entransy Dissipation Extremum Principle, Performed at the Naval University of Engineering; a Review

Entropy, 2018
Combining entransy theory with constructal theory, this mini-review paper summarizes the constructal optimization work of heat conduction, convective heat transfer, and mass transfer problems during the authors’ working time in the Naval University of ...
Lingen Chen, Qinghua Xiao, Huijun Feng
doaj   +1 more source