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Optogenetic Interneuron Stimulation and Calcium Imaging in Astrocytes
2019In brain networks, neurons are constantly involved in a dynamic interaction with the other cell populations and, particularly, with astrocytes, the most abundant glial cells in the brain. Astrocytes respond to neurotransmitters with Ca2+ elevations which represent a key event in the modulation of local brain circuits played by these glial cells. Due to
Losi, Gabriele +4 more
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Patterned Optogenetic Stimulation Using a DMD Projector
2020Optical manipulation is a powerful way to control neural activity in vitro and in vivo with millisecond precision. Patterning of light provides the remarkable ability to simultaneously target spatially segregated neurons from a population. Commercially available projectors provide one of the simplest and most economical ways of achieving spatial light ...
Aanchal, Bhatia +2 more
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Optogenetic Stimulation of the Central Amygdala Using Channelrhodopsin
2020Optogenetics allows for the targeted temporary inhibition or stimulation of specific brain regions in vivo with precise temporal resolution. Here, we describe the steps to perform intracranial optogenetic surgery in rodents as well as instructions to build an optogenetic headcap and set up an optogenetic testing environment to conduct experiments ...
Anna S, Knes +2 more
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Myo-optogenetics: optogenetic stimulation and electrical recording in skeletal muscles
Abstract Complex movements involve highly coordinated control of local muscle elements. Highly controlled perturbations of motor outputs can reveal insights into the neural control of movements. Here we introduce an optogenetic method, compatible with electromyography (EMG) recordings, to perturb muscles in transgenic mice.Jeong Jun Kim +6 more
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Optogenetic stimulation: Understanding memory and treating deficits
Hippocampus, 2018AbstractTechnology allowing genetically targeted cells to be modulated by light has revolutionized neuroscience in the past decade, and given rise to the field of optogenetic stimulation. For this, non‐native, light activated proteins (e.g., channelrhodopsin) are expressed in a specific cell phenotype (e.g., glutamatergic neurons) in a subset of ...
Barnett, SC +3 more
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Wireless optogenetic neural dust for deep brain stimulation
2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom), 2016In recent years, numerous research efforts have been dedicated towards developing efficient implantable devices for Deep Brain Stimulation (DBS). However, there are limitations and challenges with the current technologies. Firstly, the stimulation of neurons currently is only possible through implantable electrodes which target a population of neurons.
Stefanus A. Wirdatmadja +3 more
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An Integrated μLED Optrode for Optogenetic Stimulation and Electrical Recording
IEEE Transactions on Biomedical Engineering, 2013In this letter, we developed an integrated neural probe prototype for optogenetic stimulation by microscale light-emitting diode (μLED) and simultaneous recording of neural activities with microelectrodes on a single-polyimide platform. Optogenetics stimulates in vivo neural circuits with high-cellular specificity achieved by genetic targeting and ...
Hung Cao +3 more
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Adapting NeuroRighter for in vivo optogenetic stimulation
2013 6th International IEEE/EMBS Conference on Neural Engineering (NER), 2013The temporal and cell-type specific precision of optogenetics provides effective functional dissection of the intact nervous system. Integrating these techniques with existing multielectrode electrophysiological recording methods is essential in realizing this goal.
Nealen G. Laxpati +2 more
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Glass optrode arrays for optogenetic stimulation
SPIE Proceedings, 2013Early-generation penetrating waveguide arrays made of glass (SiO2) were micromachined for optogenetic stimulation in able to provide comprehensive and selective access to distributed targets in three dimensions. We characterized light delivery of the device in order to facilitate design optimization and understand its application in tissue.
T. V. F. Abaya +6 more
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Optogenetic stimulation of myelination (Conference Presentation)
Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 2016Myelination is governed by axon-glia interaction which is modulated by neural activity. Currently, the effects of subcellular activation of neurons which induce neural activity upon myelination are not well understood. To identify if subcellular neuronal stimulation can enhance myelination, we developed a novel system for focal stimulation of neural
In Hong Yang +2 more
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