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Towards the Clinical Translation of Optogenetic Skeletal Muscle Stimulation
Pflugers Archiv European Journal of Physiology, 2020 Paralysis is a frequent phenomenon in many diseases, and to date, only functional electrical stimulation (FES) mediated via the innervating nerve can be employed to restore skeletal muscle function in patients.
Dirk Beutner +2 more
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Adaptive Control of Sinusoidal Optogenetic Stimulation
2021 10th International IEEE/EMBS Conference on Neural Engineering (NER), 2021Hippocampal theta oscillations are associated with cognitive functions and their disorder has been linked with pathological conditions, such as temporal lobe epilepsy and Alzheimer's disease. Brief periods of theta-band stimulation have been shown to promote therapeutical effects in neurological disease models.
Diego M. Vieira +4 more
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Considering optogenetic stimulation for cochlear implants
Hearing Research, 2015Electrical cochlear implants are by far the most successful neuroprostheses and have been implanted in over 300,000 people worldwide. Cochlear implants enable open speech comprehension in most patients but are limited in providing music appreciation and speech understanding in noisy environments.
Marcus Jeschke, Tobias Moser
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Transdermal optogenetic peripheral nerve stimulation
Journal of Neural Engineering, 2017Abstract Objective: A fundamental limitation in both the scientific utility and clinical translation of peripheral nerve optogenetic technologies is the optical inaccessibility of the target nerve due to the significant scattering and absorption of light in biological tissues.
Benjamin E, Maimon +7 more
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Active Control of μLED Arrays for Optogenetic Stimulation
2018 IEEE International Symposium on Circuits and Systems (ISCAS), 2018Optical neural stimulation using optogenetic technique plays an important role in neuroscience applications and neuroprosthetic solutions. Most optogenetic applications require power efficient photostimulation tools that can provide sufficient optic power for stimulation of photosensitized neural cells with desired spatial and temporal resolutions.
Leila Montazeri +4 more
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Omnidirectional optogenetic stimulation
Nature Electronics, 2018A wireless, low-power optoelectronic platform, which is based on micro-LEDs, can provide multimodal programmable control over optogenetic stimulation parameters.
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Fiber-optic two-photon optogenetic stimulation
Optics Letters, 2013Optogenetic stimulation of genetically targeted cells is proving to be a powerful tool in the study of cellular systems, both in vitro and in vivo. However, most opsins are activated in the visible spectrum, where significant absorption and scattering of stimulating light occurs, leading to low penetration depth and less precise stimulation.
K, Dhakal, L, Gu, B, Black, S K, Mohanty
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Optogenetics and Deep Brain Stimulation Neurotechnologies
2015Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines light and genetic methods to control or monitor neural activity patterns, has proven to be ...
Kondabolu, Krishnakanth +3 more
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A stimulation platform for optogenetic and bionic vision restoration
2017 IEEE International Symposium on Circuits and Systems (ISCAS), 2017Optogenetic therapy holds the promise to restore visual function in patients affected by retinal degenerative diseases. However, the light-sensitivity of the molecule mediating light responses is much less than the one of healthy retinal cells so that no photo-stimulation is expected under natural environmental conditions.
Francesco Galluppi +9 more
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Two-Photon Optogenetic Stimulation of Drosophila Neurons
2020Optogenetics enables experimental control over neural activity using light. Channelrhodopsin and its variants are typically activated using visible light excitation but can also be activated using infrared two-photon excitation. Two-photon excitation can improve the spatial precision of stimulation in scattering tissue but has several practical ...
Mehmet, Fişek, James M, Jeanne
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