Results 61 to 70 of about 704,312 (278)

Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]

open access: yes2018 IEEE International Conference on Communications (ICC), 2018
This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron's membrane potential and its firing times.
Adam Noel   +3 more
openaire   +3 more sources

Optoception: perception of optogenetic brain stimulation [PDF]

open access: yes, 2021
Summary How do animals experience brain manipulations? Optogenetics has allowed us to manipulate selectively and interrogate neural circuits underlying brain function in health and disease. However, it is currently unknown whether mice could perceive arbitrary optogenetic stimulation in addition to their evoked physiological functions ...
Jorge Luis-Islas   +3 more
openaire   +1 more source

2D Skeletal Muscle Thin Film Actuators Enhance Efficiency of Biohybrid Robots

open access: yesAdvanced Functional Materials, EarlyView.
2D skeletal muscle thin film actuators generate millinewton‐scale forces and millimeter‐scale strokes while remaining functional for over 30 days. Their force density is 20‐fold higher than 3D skeletal muscle actuators, enabling multi‐fin robots with tunable speed and multidirectional steering.
Maheera Bawa   +5 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

open access: yesAdvanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou   +6 more
wiley   +1 more source

Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice

open access: yesScientific Reports, 2022
Non-invasive stimulation technologies are emerging as potential treatment options for a range of neurodegenerative disorders. Experimental evidence suggests that stimuli-evoked changes in slow brain rhythms may mitigate or even prevent neuropathological ...
Stephen Thankachan   +4 more
doaj   +1 more source

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

open access: yesAdvanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee   +15 more
wiley   +1 more source

Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically contain a C-terminal fluorescent protein (FP) tag for visualization that ...
Maria Zerche   +4 more
doaj   +1 more source

Electrophysiology-based Closed Loop Optogenetic Brain Stimulation Devices: Recent Developments and Future Prospects

open access: yes, 2022
Electrophysiology-based Closed Loop Optogenetic Brain Stimulation Devices: Recent Developments and Future ...
Abbas Kouzani (13079637)   +1 more
core  

Optogenetic stimulation of astrocytes causes an overall inhibitory effect in the hippocampal CA1

open access: yes, 2021
As optogenetics offers a promising strategy in treating pathological conditions, optogenetic application in astrocytes could be a better alternative intervention because it bypasses direct manipulation of neurons.
Theint, Aye Theint   +2 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

open access: yesAdvanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa   +7 more
wiley   +1 more source

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