Results 101 to 110 of about 58,764 (371)
Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications
Advanced Healthcare Materials, EarlyView.This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin +6 more
wiley +1 more source
Illuminating pathogen-host intimacy through optogenetics.
PLoS Pathogens, 2018 The birth and subsequent evolution of optogenetics has resulted in an unprecedented advancement in our understanding of the brain. Its outstanding success does usher wider applications; however, the tool remains still largely relegated to neuroscience ...
Ruben Dario Arroyo-Olarte +3 more
doaj +1 more source
From channelrhodopsins to optogenetics
EMBO Molecular Medicine, 2013 We did not expect that research on the molecular mechanism of algal phototaxis or archaeal light‐driven ion transport might interest readers of a medical journal when we conceived and performed our experiments a decade ago. On the other hand, it did not escape our attention that channelrhodopsin is helping an ever‐increasing number of researchers to ...
Peter Hegemann, Georg Nagel
doaj +4 more sources
The Dawning of Primate Optogenetics [PDF]
Neuron, 2009 In this issue of Neuron, Han and colleagues bring optogenetic methods into use in nonhuman primates by demonstrating the feasibility of achieving cell-type-specific photoactivation of macaque neocortical neurons. The use of optogenetic approaches in nonhuman primates promises to revolutionize our understanding of the neural circuitry that mediates ...
Tamara Berdyyeva, John V. Reynolds
openaire +3 more sources
Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex
Advanced Healthcare Materials, EarlyView.Delivering light deep into the brain over a large volume while causing minimal tissue damage is a major challenge for non‐human primate optogenetics. This study evaluates Utah Optrode Array designs in vivo, revealing how changes in shank geometry, surface texture, and insertion parameters minimize acute damage—offering a path toward high‐precision ...
Adrián Villamarin‐Ortiz +8 more
wiley +1 more source
BioTechniques, 2014 It has been a decade since researchers first showed they could control neurons with light. Jeffrey Perkel takes a look at the technique that changed how we study the brain.
Jeffrey M. Perkel
doaj +1 more source
Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
, 2016 Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark +5 more
core +1 more source
Corrigendum: Optogenetics [PDF]
Current Biology, 2011 SummaryThe standfirst of the feature “Shining new light on the brain” (Curr. Biol. (2011), 21, R831–R833) stated that optogenetic control of neurons has only been around for six years. It has now come to our attention that the fundamental concept of targeting sensitivity to light to specific neurons, so that their electrical activity could be ...
openaire +1 more source
Advanced Healthcare Materials, EarlyView.An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai +9 more
wiley +1 more source
Bringing Optogenetics to the Synapse [PDF]
Neuron, 2013 In this issue of Neuron, Lin et al. (2013) describe InSynC, an optogenetic approach that utilizes chromophore-assisted light inactivation (CALI) to inactivate presynaptic neurotransmitter release proteins VAMP2 and synaptophysin. InSynC selectively reduces synaptic transmission in illuminated regions in vitro and in vivo.
Ehud Y. Isacoff +5 more
openaire +3 more sources