Results 151 to 160 of about 43,018 (315)
Advanced Science, EarlyView.PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang +7 more
wiley +1 more source
Advanced Science, EarlyView.Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang +3 more
wiley +1 more source
Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release [PDF]
, 2021 Jacob A. Nadel +9 more
openalex +1 more source
Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes
Advanced Science, EarlyView.The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui +8 more
wiley +1 more source
Targeted cell ablation in zebrafish using optogenetic transcriptional control [PDF]
, 2020 K Mruk +4 more
openalex +1 more source
Traceless Regulation of Genetic Circuitry
Advanced Science, EarlyView.Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance
Advanced Science, EarlyView.DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin +15 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.This paper reviews the physics of liquid metals in RF devices, including the influence of mechanical strain on resonance as well as fabrication methods and strategies for designing tunable and strain‐tolerant inductors, capacitors, and antennas.
Md Saifur Rahman, William J. Scheideler
wiley +1 more source
Optogenetics to help exploring the cerebral blood flow regulation [PDF]
, 2014 Pìotr Bregestovski, Yuri Zilberter
openalex +1 more source