Results 171 to 180 of about 21,147 (255)

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source

Optogenetic stimulation attenuates central post-stroke pain via BDNF/TrkB signaling pathway modulation in the ascending pain modulation system. [PDF]

Sci Rep
Gu YJ, Chang J, Deng F, Deng C.
europepmc   +1 more source

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Silvia Gasparini, Haidong Zhu, Ana Sofia Peraza Munuzuri, Mya L. Leuang, Frederico S. Fazan, Joel C. Geerling   +5 more
wiley   +1 more source

Oxytocin and Vasopressin Cross Talk Within the Brain Increases Blood Pressure. [PDF]

Circ Res
Elsaafien K, Kirchner MK, Baumer-Harrison C, Tan Y, Johnson DN, Vincent CJ, Scott KA, Zhou J, Zhang Y, Lang Y, Bulitta J, Stern JE, de Kloet AD, Krause EG.   +13 more
europepmc   +1 more source

An Olfactory Piriform Cortex‐Lateral Hypothalamus Neural Circuit Contributes to Linalool‐Induced Analgesia

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Linalool odor exposure activates a glutamatergic projection from the piriform cortex to the lateral hypothalamus (PiriGlu‐LH), mediating descending inhibitory pain pathways. This demonstrates a novel neural mechanism for olfactory‐induced pain modulation and suggests potential therapeutic implications for pain management.
Yunhe Zhu, Jingping Sun, Shan Wang, Qidong Zhang, Jian Mao, Guobi Chai, Qingzhao Shi, Wu Fan, Jianping Xie   +8 more
wiley   +1 more source

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06). [PDF]

Adv Genet (Hoboken)
Duan X, Zhu M, Gao S.
europepmc   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Transforming Epilepsy Care: A Comprehensive Review of Technological Innovations, Artificial Intelligence Advancements, and Precision Tools for Enhanced Seizure Management and Patient Outcomes. [PDF]

Scientifica (Cairo)
Shyam M, Kaushal N, Yadav M, Srirangan P, Prince SE.   +4 more
europepmc   +1 more source

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source