Results 161 to 170 of about 55,224 (387)
Corrigendum: Optogenetics [PDF]
Current Biology, 2011 SummaryThe standfirst of the feature “Shining new light on the brain” (Curr. Biol. (2011), 21, R831–R833) stated that optogenetic control of neurons has only been around for six years. It has now come to our attention that the fundamental concept of targeting sensitivity to light to specific neurons, so that their electrical activity could be ...
openaire +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
Advanced Science, EarlyView.LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao +7 more
wiley +1 more source
Structures and functions of cilia during vertebrate embryo development
Molecular Reproduction and Development, Volume 89, Issue 12, Page 579-596, December 2022., 2022 Abstract Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells have an immotile primary cilium that mediates cell signaling, and some specialized cells assemble one or multiple cilia that are motile and beat synchronously to move fluids in one direction.
Jeffrey D. Amack
wiley +1 more source
In Situ Light‐driven pH Modulation for NMR Studies
Angewandte Chemie, EarlyView.In this work, we introduce a novel approach to control pH in NMR samples using light‐activated photoacids. By combining light stimuli with pH‐sensitive molecules, we demonstrate the ability to precisely modulate pH without physically manipulating the sample.
Aarav Barde +6 more
wiley +2 more sources
Optogenetic vision restoration with high resolution [PDF]
arXiv, 2018 The majority of inherited retinal degenerations are due to photoreceptor cell death. In many cases ganglion cells are spared making it possible to stimulate them to restore visual function. Several studies (Bi et al., 2006; Lin et al., 2008; Sengupta et al., 2016; Caporale et al., 2011; Berry et al., 2017) have shown that it is possible to express an ...
arxiv
From channelrhodopsins to optogenetics
EMBO Molecular Medicine, 2013 We did not expect that research on the molecular mechanism of algal phototaxis or archaeal light‐driven ion transport might interest readers of a medical journal when we conceived and performed our experiments a decade ago. On the other hand, it did not escape our attention that channelrhodopsin is helping an ever‐increasing number of researchers to ...
Hegemann, Peter, Nagel, Georg
openaire +4 more sources
Depth‐Customizable 3D Electrode Array for Recording Functional Connectivity in the Brain
Advanced Electronic Materials, EarlyView.In this study, a depth‐adjustable, flexible 3D multi‐shank electrode array that produces precise neural recordings at various brain depths is developed. Integrating 2D flexible electrode arrays with a modular supporting board allowed the insertion depth to be easily adjusted without re‐fabrication.
Minseok Kim +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Introducing remote silyl groups into coumarin derivatives enhances their hydrolytic stability and photocleavage efficiency. This innovative molecular design enables efficient protein release from solid phase material upon photo irradiation, advancing applications in chemical biology and photomanipulation.
Masahiko Yoshimura +5 more
wiley +2 more sources
Real-Time Phase Masks for Interactive Stimulation of Optogenetic Neurons [PDF]
arXiv, 2013 Experiments with networks of optogenetically altered neurons require stimulation with high spatio-temporal selectivity. Computer-assisted holography is an energy-efficient method for robust and reliable addressing of single neurons on the millisecond-timescale inherent to biologial information processing.
arxiv
Blue-Light Receptors for Optogenetics.
Chemical Reviews, 2018 Sensory photoreceptors underpin light-dependent adaptations of organismal physiology, development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors become genetically encoded actuators and reporters to enable the noninvasive ...
A. Losi, K. Gardner, Andreas Möglich
semanticscholar +1 more source