Results 161 to 170 of about 58,764 (371)

The status and challenges of optogenetic tools for precise spatiotemporal control of RNA metabolism and function

Clinical and Translational Medicine, 2022
Renmei Liu, Mengyue Fang, Xianjun Chen, Yi Yang   +3 more
doaj   +1 more source

Cardiac Optogenetics and Optical Mapping – Overcoming Spectral Congestion in All-Optical Cardiac Electrophysiology

Frontiers in Physiology, 2019
Optogenetic control of the heart is an emergent technology that offers unparalleled spatio-temporal control of cardiac dynamics via light-sensitive ion pumps and channels (opsins). This fast-evolving technique holds broad scope in both clinical and basic
Christopher O’Shea, Christopher O’Shea, Christopher O’Shea, Andrew P. Holmes, Andrew P. Holmes, James Winter, Joao Correia, Xianhong Ou, Ruirui Dong, Shicheng He, Paulus Kirchhof, Paulus Kirchhof, Larissa Fabritz, Larissa Fabritz, Kashif Rajpoot, Davor Pavlovic   +15 more
doaj   +1 more source

Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system [PDF]

, 2009
Peixin Zhu
openalex   +1 more source

Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice

Advanced Science, EarlyView.
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao   +9 more
wiley   +1 more source

Optogenetic therapeutic strategies for diabetes mellitus

Journal of Diabetes
Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It is characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction of insulin sensitivity and functionality.
Xin Deng, Dandan Peng, Yuanfa Yao, Ke Huang, Jinling Wang, Zhihao Ma, Junfen Fu, Yingke Xu   +7 more
doaj   +1 more source

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex [PDF]

, 2010
Herbert E. Covington, Mary Kay Lobo, Ian Maze, Vincent Vialou, James M. Hyman, Samir Zaman, Quincey LaPlant, Ezekiel Mouzon, Subroto Ghose, Carol A. Tamminga, Rachael L. Neve, Karl Deisseroth, Eric J. Nestler   +12 more
openalex   +1 more source

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics [PDF]

, 2010
Viviana Gradinaru, Feng Zhang, Charu Ramakrishnan, Joanna Mattis, Rohit Prakash, Ilka Diester, Inbal Goshen, Kimberly R. Thompson, Karl Deisseroth   +8 more
openalex   +1 more source

Acute silencing of hippocampal CA3 reveals a dominant role in place field responses. [PDF]

, 2019
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller ...
Davoudi, Heydar, Foster, David J
core  

Optogenetics: development and application [PDF]

Neuroscience Research, 2009
Integrating microbial opsins and solid-state optics allows millisecond-precision bidirectional control of defined cell types in freely behaving mammals. Following the introduction of the microbial opsin genes ChR2 and NpHR to neurobiology, genomic strategies allowed the discovery and adaptation for neuroscience of a third major optogenetic tool, namely
openaire   +3 more sources