Results 171 to 180 of about 55,224 (387)
American Journal of Physiology-Heart and Circulatory Physiology, 2013 Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be sensitized to respond to light by a relatively simple and well-tolerated genetic modification using microbial opsins (light-gated ion channels and pumps).
openaire +3 more sources
Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease
Aggregate, EarlyView.This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang +4 more
wiley +1 more source
Hydrogel‐Based Smart Materials for Wound Healing and Sensing
Aggregate, EarlyView.The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong +11 more
wiley +1 more source
Visible‐light‐switchable azobenzenes: Molecular design, supramolecular systems, and applications
Natural Sciences, Volume 3, Issue 1, January 2023., 2023 Abstract Photocontrol of functional molecules and supramolecular systems provides promising directions for the development of innovative materials and technologies. Reversible photoswitches that can isomerize among different states play a vital role in such photoresponsive systems. However, the commonly used UV light for triggering the isomerization of
Minghao Gao +3 more
wiley +1 more source
Thermal constraints on in vivo optogenetic manipulations. [PDF]
, 2019 A key assumption of optogenetics is that light only affects opsin-expressing neurons. However, illumination invariably heats tissue, and many physiological processes are temperature-sensitive.
Kreitzer, Anatol C +2 more
core
Advanced Intelligent Systems, EarlyView.The integration of sensing elements in bioengineered actuators is key to obtain real‐time information about their performance and further control/automation. By coupling flexible organic field‐effect transistor to a skeletal muscle actuator we demonstrate the feasibility to record in real‐time its contractile behavior when stimulated by electrical ...
Stefano Lai +5 more
wiley +1 more source
The past, present and future of light-gated ion channels and optogenetics
eLife, 2018 The discovery of the mechanisms underlying light-gated ion channels called channelrhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry.
Sheena A Josselyn
doaj +1 more source
Probing neural codes with two-photon holographic optogenetics
Nature Neuroscience, 2021 H. Adesnik, L. Abdeladim
semanticscholar +1 more source
Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots
Advanced Intelligent Systems, EarlyView.Skeletal muscle tissue‐based bioactuators move in response to externally applied electrical stimuli in open‐loop control, which lacks knowledge of the actuator's state. Herein, a soft and fiber‐shaped piezoresistive mechanosensor that integrates with the soft tissue and operates in the cell culture environment is used to create the first proprioceptive
Miriam Filippi +8 more
wiley +1 more source