Results 151 to 160 of about 7,612 (259)

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

open access: yesHead &Neck, Volume 48, Issue 9, Page 2364-2376, September 2026.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam   +10 more
wiley   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

open access: yesHead &Neck, Volume 48, Issue 9, Page 2377-2393, September 2026.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik   +6 more
wiley   +1 more source

Non‐Metastatic Squamous Cell Carcinoma of the Oropharynx: Primary Surgery or (Chemo)radiotherapy?

open access: yesHead &Neck, Volume 48, Issue 9, Page 2541-2556, September 2026.
ABSTRACT Background In patients with locally advanced, non‐metastatic oropharyngeal squamous cell carcinoma (OPSCC), surgery‐based and nonsurgical treatment approaches have not been adequately compared in randomized Phase III clinical trials. Current clinical guidelines recommend various surgical and nonsurgical strategies across disease stages for ...
Primož Strojan   +12 more
wiley   +1 more source

Artificial Intelligence–Driven MRI for Cervical Nodal Metastasis Detection in Oral Squamous Cell Carcinoma: A Hierarchical Meta‐Analysis of Diagnostic Accuracy

open access: yesHead &Neck, Volume 48, Issue 9, Page 2557-2569, September 2026.
ABSTRACT Background Artificial intelligence (AI) applied to magnetic resonance imaging (MRI) may improve detection of cervical lymph node metastases in oral squamous cell carcinoma (OSCC) but is heterogeneous. Methods A systematic review identified observational studies (from 2000) evaluating AI‐based MRI in adults with histopathologically confirmed ...
José Evando da Silva‐Filho   +8 more
wiley   +1 more source

Demographic and clinical presentations of keratoconus in Trinidad and Tobago: a retrospective study. [PDF]

open access: yesBMC Ophthalmol
Ezinne NE   +5 more
europepmc   +1 more source

The Effect of Micronutrient Intake and Supplementation on Prevalent Diabetes‐Related Foot Ulcer and Incident Hospitalisation for Diabetes‐Related Foot Ulcer in Type 2 Diabetes: The Fremantle Diabetes Study Phase 2

open access: yesJournal of Foot and Ankle Research, Volume 19, Issue 3, September 2026.
ABSTRACT Objective To determine whether micronutrient intake and/or supplementation is associated with prevalent diabetes‐related foot ulcer (DFU) and/or incident hospitalisation for DFU in type 2 diabetes. Research Design and Methods Participants with type 2 diabetes from the community‐based Fremantle Diabetes Study Phase II (FDS2; 1499 participants ...
Emma J. Hamilton   +4 more
wiley   +1 more source

Appropriate Care and Support for People With Down Syndrome in the Netherlands

open access: yesJournal of Policy and Practice in Intellectual Disabilities, Volume 23, Issue 3, September 2026.
ABSTRACT The (often complex) needs experienced by people with Down syndrome are not always sufficiently answered by available care and support. This paper aims to provide insight into what appropriate care and support for people with Down syndrome in the Netherlands entails and how it could be optimised.
Francine A. van den Driessen Mareeuw   +3 more
wiley   +1 more source

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