Results 21 to 30 of about 6,988 (158)

La elaboración de El turista

open access: yesVia@, 2018
El autor reflexiona sobre el contexto histórico y las bases intelectuales e institucionales para su (1976) estudio: The Tourist: Una Nueva Teoría de sobre esta Clase de ocio, especialmente sus conexiones con la teoría clásica y de crítica social, y sus ...
Dean MacCannell
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Reseñas

open access: yesPáginas, 2016
CASTELLANOS, Santiago, En el final de Roma (ca. 455-480): la solución intelectual, Ediciones de Historia, Marcial Pons, Madrid,  2013 POY, Lucas, Los orígenes de la clase obrera; huelgas, sociedades de resistencia y militancia política en Buenos Aires ...
Viviana Talavera   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Who writes «the-book-that-I-do-not-write» ? Appellate capacity in Cixous' early and late works

open access: yesFeminismo/s, 2006
Reading three recent texts of Cixous Les Rêveries de la femme sauvage, Tours promises et Le jour où je n’étais pas là, this article wants to explore the question of pairing or doubling (the mother, brother, sister, daughter, the Twin Towers, the ...
Cathérine Mavrikakis
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Los inicios de la experiencia coopeativa Mondragón

open access: yesRevista de Estudios Cooperativos, 2014
Este artículo analiza los orígenes y la evolución inicial de la Experiencia Cooperativa Mondragón (ECM). A lo largo de estas tres décadas (1955-1985), se produce el surgimiento y la consolidación de la ECM. Esta Experiencia, radicalmente innovadora en su
Rafael Altuna, Eguzki Urteaga
doaj   +1 more source

Sociología del Deporte en España: una actualización (2005-2017). [Sociology of Sport in Spain: an update (2005-2017)]. [PDF]

open access: yesRevista Internacional de Ciencias del Deporte, 2018
El presente artículo comienza explicando cuáles son los orígenes de la Sociología del Deporte en España los cuales que se sitúan en los tiempos de la Transición (1975-1983); durante estos años, el deporte se va convirtiendo progresivamente de ser un ...
Nuria Puig, Anna Vilanova, Pau Mateu
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

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