Results 31 to 40 of about 486,441 (203)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Los orígenes del diagnóstico médico [PDF]
, 1981 Parodiando una conocida ingeniosidad académica, podría decirse que el diagnóstico médico comenzó por no existir. O bien, ya sin ingeniosidad alguna, que en la historia de la humanidad ha existido una primera etapa en la cual los sanadores no ...
Laín Entralgo, Pedro
core +2 more sources
Advanced Healthcare Materials, EarlyView.Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu +10 more
wiley +1 more source
Who writes «the-book-that-I-do-not-write» ? Appellate capacity in Cixous' early and late works
Feminismo/s, 2006 Reading three recent texts of Cixous Les Rêveries de la femme sauvage, Tours promises et Le jour où je n’étais pas là, this article wants to explore the question of pairing or doubling (the mother, brother, sister, daughter, the Twin Towers, the ...
Cathérine Mavrikakis
doaj +1 more source
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Los inicios de la experiencia coopeativa Mondragón
Revista de Estudios Cooperativos, 2014 Este artículo analiza los orígenes y la evolución inicial de la Experiencia Cooperativa Mondragón (ECM). A lo largo de estas tres décadas (1955-1985), se produce el surgimiento y la consolidación de la ECM. Esta Experiencia, radicalmente innovadora en su
Rafael Altuna, Eguzki Urteaga
doaj +1 more source
El viajero y la ilustración (I): orígenes ideológicos en la recuperación de la antigüedad [PDF]
, 1993 El viajero y la ilustración (I): orígenes ideológicos en la recuperación de la ...
Maure Rubio, Lilia Paloma
core +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
La «Communio»: unidad y diversidad en torno a Nicea. [PDF]
, 2009 El Concilio de Nicea, con sus prolegómenos y consecuencias, puede ser visto en algunas de sus facetas, como un ejemplo del compromiso entre la verdadera comunión eclesial y la efímera comunión política.
Navascués, P. (Patricio) de
core
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source