Results 51 to 60 of about 86,733 (198)

Sobre los demostrativos: orígenes y evolución

open access: yes, 2000
Sobre los demostrativos: orígenes y ...
Egido Fernández, María Cristina   +1 more
core   +1 more source

El espacio intermedio y los orígenes del Team X [PDF]

open access: yes, 2014
El espacio intermedio y los orígenes del Team
Juárez Chicote, Antonio   +1 more
core   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

Los Jesuitas: Orígenes, logros y estrategia: Array

open access: yes, 2021
Los Jesuitas: Orígenes, logros y ...
Beaumont, S. J. , Guilermo
core  

Nuevos años de Orígenes [PDF]

open access: yes, 2007
Fil: Arcos La Rosa, Jorge L. Revista Encuentro de la Cultura Cubana; EspañaEnsayo sobre la publicación de Los años de Orígenes, de Lorenzo García ...
Arcos La Rosa, Jorge L.
core   +2 more sources

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen   +12 more
wiley   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

open access: yesAdvanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami   +7 more
wiley   +1 more source

Orígenes del Partido Andalucista

open access: yes, 1985
Informe sobre los orígenes del Partido Andalucista redactado por Alejandro Rojas ...
Rojas Marcos, Alejandro
core   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

open access: yesAdvanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran   +10 more
wiley   +1 more source

Evolución histórica, táctica y estructural del sistema de juego defensivo 5:1 en balonmano

open access: yesApunts: Educación Física y Deportes, 2012
El presente artículo tiene por objeto establecer las pautas evolutivas que desde el punto de vista físico, técnico, táctico y antropométrico ha sufrido el sistema de juego defensivo 5:1 en balonmano.
José Julio Espina Agulló   +2 more
doaj   +1 more source

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