Results 31 to 40 of about 5,655,076 (289)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Content Readability Levels in New Media About "Social Media Addiction": Websites in Turkish

open access: yesYeni Medya
This research aims to examine the informative content readability levels of Turkish websites about social media addiction using an interdisciplinary approach.
Rufen Oral
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Selefin ve Halefin Tevil Yaklaşımları ve Bunun Tefsire Yansımaları

open access: yesAntakiyat, 2022
Kavramlara yüklenen anlamlar, onlara yönelik yaklaşımların belirlenmesinde büyük bir öneme sahiptir. Dolayısıyla muhatabın bir kavram ile ilgili algısının mahiyetini doğru bir şekilde anlayabilmek için onun o kavrama yüklediği anlamları bilmek gerekir ...
Murat Oral
doaj  

Meaning Management: A Framework for Leadership Ontology [PDF]

open access: yes, 2019
Leadership is a multifaceted and complex subject of research and demands a sound ontological stance that guides studies for the development of more integrative leadership theories.
Oral, Muhittin
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

HABİB EN-NECCAR’IN ANTAKYA HALKINA TAVSİYE ETTİĞİ PSİKOSOSYAL HİKMETLER

open access: yesMehmet Akif Ersoy Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2020
Habîb en-Neccâr, Hz. İsa’nın peygamberliği döneminde Antakya’da yaşadığı tahmin edilen biridir. O dönemde bir şehir halkına tevhid dinini tebliğ etmeleri için Allah (veya Hz. İsa) elçilerini gönderir.
Osman Oral
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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