No relation between docetaxel administration route and high‐grade diarrhea incidence
Pharmacology Research & Perspectives, 2020 Oral administration of docetaxel in combination with the CYP3A4 inhibitor ritonavir is used in clinical trials to improve oral bioavailability of docetaxel. Diarrhea was the most commonly observed and dose‐limiting toxicity.
Jeroen J. M. A. Hendrikx +9 more
doaj +1 more source
Elevated central serotonin levels inhibit emotional crying [PDF]
, 2010 Previous research has suggested a possible role of serotonin in emotional expressions, such as crying. We have found that a transient increase of central serotonin levels by means of oral administration of paroxetine reduces crying in response to ...
Ad Vingerhoets +3 more
core +1 more source
Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries [PDF]
, 2011 <p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth ...
Baker, A.H. +10 more
core +1 more source
Effect of henbane seed on acute and chronic painin male rats [PDF]
Introduction: Recent studies have shown that anticholinergic alkaloid compounds have antinociceptive property. Regarding to the presence of anticholinergic alkaloid compounds in henbane (hyoscyamus niger) and due to the expressing of this plant as ...
خلیلی, محسن +2 more
core
Different effects of oral and transdermal hormone replacement therapies on Factor IX, APC resistance, t-PA, PAI and C- reactive protein - a cross-sectional population survey [PDF]
, 2001 The effects of hormone replacement therapy (HRT) on thrombosis risk, thrombotic variables, and the inflammatory marker C- reactive protein (CRP) may vary by route of administration (oral versus transdermal).
Lowe, G.D.O. +5 more
core
A case of rhinoscleroma treated with ciprofloxacin [PDF]
, 2001 Respiratory scleroma (often termed \'rhinoscleroma\') is a chronic inflammatory condition in which deforming masses of tissue distend the nasal cavity. Klebsiella rhinoscleromatis is the causative agent of this infection and the Mikulicz cell is specific
Badia, L, Lund, VJ
core +1 more source
Prevention of Adiposity by the Oral Administration of ?-Cryptoxanthin [PDF]
Frontiers in Neurology, 2011 β-Cryptoxanthin (β-CRX) is a carotenoid found in human blood. It is specifically rich in Satsuma mandarin (Citrus unshiu Marc.) but very little in other fruits or vegetables. Several reports indicate the health promoting benefits of β-CRX. As we had reported visceral fat reduction on mildly obese male by the oral administration of β-CRX, a detailed ...
openaire +3 more sources
Ramsay Hunt syndrome a case report and review of literature [PDF]
, 2013 This is a case report of a rather rare disorder i.e. Ramsay Hunt syndrome. This is caused by Varicella zoster infections involving geniculate ganglion of facial nerve. This syndrome is manifested by the presence of blebs in the external auditory canal,
Thiagarajan, Balasubramanian
core +1 more source
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Pharmaceutics, 2019 Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects.
B. Homayun, Xueting Lin, Hyo-Jick Choi
semanticscholar +1 more source
An integrated pharmacokinetic and pharmacodynamic study of a new drug of abuse, methylone, a synthetic cathinone sold as 'bath salts' [PDF]
, 2013 Material and methods. Methylone was administered to male Sprague-Dawley rats intravenously (10 mg/kg) and orally (15 and 30 mg/kg). Plasma concentrations and metabolites were characterized by LC/MS and LC-MS/MS fragmentation patterns.
Barrett +43 more
core +2 more sources