Results 51 to 60 of about 1,538,497 (307)

The Novel Oral Anticoagulants [PDF]

open access: yesSeminars in Thrombosis and Hemostasis, 2013
After the introduction of warfarin, long-term oral anticoagulation treatment remained unchanged for more than 50 years. Most recently, with the development and approval of new oral anticoagulants, the treatment of medical conditions that require thrombosis prophylaxis and long-term anticoagulation has become more complex.
Cristhiam M, Rojas-Hernandez   +1 more
openaire   +2 more sources

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

NEW PROSPECTS IN THE SECONDARY PREVENTION OF VENOUS THROMBOSIS

open access: yesАтеротромбоз, 2016
The article tells about the current strategy of secondary prevention of venous thrombosis. The benefits and potential risks of oral anticoagulants are evaluated. The possibility of taking acetylsalicylic acid, if new oral anticoagulants  are excluded, is
P. S. Laguta
doaj   +1 more source

Final Analysis of the BRUIN Phase 1/2 Study Assessing the Safety and Efficacy of Pirtobrutinib Monotherapy in Patients With MCL

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib, a highly selective, non‐covalent Bruton tyrosine kinase inhibitor (BTKi) previously demonstrated durable efficacy and tolerable safety following covalent (c) BTKi therapy in heavily pretreated relapsed/refractory (R/R) mantle cell lymphoma (MCL).
Michael L. Wang   +36 more
wiley   +1 more source

Are direct oral anticoagulants preferable to warfarin for the treatment of left ventricular thrombi? A Bayesian meta-analysis of randomized controlled trials

open access: yesAmerican Heart Journal Plus, 2021
Background: There is no clear consensus on the optimal choice of anticoagulant in patients with left ventricular thrombi (LVT). Given the potentially fatal complications associated with this disease entity, we performed a systematic review and meta ...
Ahmed Sayed   +5 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

open access: yesAnimal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen   +5 more
wiley   +1 more source

Safety profile evaluation of direct oral anticoagulants in surgical patients with polypharmacy: a retrospective analysis of clinical cases

open access: yesРеальная клиническая практика: данные и доказательства
This article presents the results of a safety study of oral anticoagulants in surgical patients with polypharmacy. An analysis of medical records of inpatients receiving oral anticoagulants for the prevention of venous thromboembolic complications was ...
E. R. Kadyseva, V. N. Khaziakhmetova
doaj   +1 more source

Management of Antithrombotic Agents in Oral Surgery Maria Martinez and Dimitrios A. Tsakiris *

open access: yesDentistry Journal, 2015
Systemic anticoagulation with intravenous or oral anticoagulants and antiplatelet agents is an efficient treatment against thromboembolic or cardiovascular disease.
Maria Martinez, Dimitrios A. Tsakiris
doaj   +1 more source

Direct-acting oral anticoagulants in antiphospholipid syndrome [PDF]

open access: yes, 2021
Antiphospholipid syndrome is an acquired autoimmune thrombophilia characterized by the development of recurrent vascular thrombosis of any caliber and type or obstetric pathology and the mandatory identification of persistently positive antiphospholipid ...
K. S. Nurbaeva, T. M. Reshetnyak
core   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

open access: yesArthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz   +13 more
wiley   +1 more source

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