Results 271 to 280 of about 2,176,373 (353)
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Enhancing Curcumin Oral Bioavailability Through Nanoformulations
European Journal of Drug Metabolism and Pharmacokinetics, 2019Curcumin is a promising therapeutic agent that exhibits manifold therapeutic activities. However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp). It is readily metabolized in the body, but many active metabolites of curcumin have been identified that could ...
Vinod S, Ipar +2 more
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Promising strategies for improving oral bioavailability of poor water-soluble drugs
Expert Opinion on Drug Discovery, 2023Introduction Oral administration of poorly water-soluble drugs (PWSDs) is generally related to low bioavailability, leading to high drug doses, multiple side effects, and low patient compliance.
B. Rocha +3 more
semanticscholar +1 more source
Bioavailability of oral dexamethasone
Clinical Pharmacology & Therapeutics, 1975Bioavailabilities of dexamethasone tablets and elixir in man were evaluated by each of 3 model‐independent methods of pharmacokinetic analysis employing plasma and urinary values as determined by radioimmune assay. There were no significant differences among the results determined by the 3 methods nor between the respective availabilities of the !Wo ...
D E, Duggan +4 more
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Drug development research (Print), 2021
Advancement in biotechnology provided a notable expansion of peptide and protein therapeutics, used as antigens, vaccines, hormones. It has a prodigious potential to treat a broad spectrum of diseases such as cancer, metabolic disorders, bone disorders ...
S. Verma +5 more
semanticscholar +1 more source
Advancement in biotechnology provided a notable expansion of peptide and protein therapeutics, used as antigens, vaccines, hormones. It has a prodigious potential to treat a broad spectrum of diseases such as cancer, metabolic disorders, bone disorders ...
S. Verma +5 more
semanticscholar +1 more source
The fate of flavonoids after oral administration: a comprehensive overview of its bioavailability
Critical reviews in food science and nutrition, 2021Despite advancements in synthetic chemistry, nature remains the primary source of drug discovery, and this never-ending task of finding novel and active drug molecules will continue.
Abid Naeem +11 more
semanticscholar +1 more source
Bioavailability of oral micronized progesterone
Fertility and Sterility, 1985Progesterone (P) has not been administered orally because of reportedly poor bioavailability and a rapid clearance rate. Unfortunately, the synthetic derivatives, although orally active, have a number of disadvantages and fail to mimic natural P completely.
W S, Maxson, J T, Hargrove
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Variable Bioavailability of Oral Melatonin
New England Journal of Medicine, 1997To the Editor: It has been claimed that melatonin has many actions, mostly on the basis of uncontrolled studies of widely varying oral doses. It is commonly assumed that the administered dosage of melatonin bears a direct relation to its circulating concentration. We estimated the bioavailability of oral melatonin by determining the pharmacokinetics of
W L, Di +3 more
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2010
Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described ...
Cave, Mark +4 more
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Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described ...
Cave, Mark +4 more
openaire +3 more sources
Absolute bioavailability of oral theophylline
American Journal of Health-System Pharmacy, 1977The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults received approximately 7.5 mg/kg theophylline intravenously over 30 minutes; either seven days before ...
L, Hendeles, M, Weinberger, L, Bighley
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