Results 281 to 290 of about 2,176,373 (353)

The Bioavailability of Oral Nitroglycerin

Journal of Pharmaceutical Sciences, 1986
In the 1970's, the efficacy of oral nitroglycerin therapy was seriously challenged, primarily on the basis of animal studies showing complete first-pass hepatic metabolism of nitroglycerin. Today, it is generally accepted that high oral doses of nitroglycerin do show antianginal efficacy. It has been suggested that this efficacy results from saturation
P K, Noonan, L Z, Benet
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Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability

AAPS PharmSciTech, 2019
Lipid-based drug delivery systems has become a popular choice for oral delivery of lipophilic drugs with dissolution rate limited oral absorption. Lipids are known to enhance oral bioavailability of poorly water-soluble drugs in multiple ways like ...
S. Talegaonkar, A. Bhattacharyya
semanticscholar   +1 more source

Self-emulsifying Drug Delivery System Improve Oral Bioavailability: Role of Excipients and Physico-chemical Characterization.

Pharmaceutical Nanotechnology, 2020
Self-emulsifying drug delivery system (SEDDS) is a kind of solid or liquid formulation composed of drugs, oil, surfactant and cosurfactant. It could form a fine emulsion (micro/nano) in the gastrointestinal tract after oral administration.
Quan Zhang, Yujin Zhu, Jing Ye
semanticscholar   +1 more source

Oral bioavailability of mesna tablets

Cancer Chemotherapy and Pharmacology, 1993
To test the feasibility of uroprotection with sodium 2-mercaptoethane-sulfonate (mesna) in tablet form the bioavailability of mesna tablets was determined in healthy volunteers by HPLC. The area under the plasma concentration-time curve (AUC) of free mesna was significantly lower following oral (110 mumol.l-1 x h-1; 95% CI 98-122) than following i.v ...
B, Stofer-Vogel, T, Cerny, M, Borner, B H, Lauterburg   +3 more
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Orally Bioavailable Competitive CCR5 Antagonists

Journal of Medicinal Chemistry, 2004
The chemokine receptor CCR5 plays an important role in inflammatory and autoimmune disorders as well as in transplant rejection by affecting the trafficking of effector T cells and monocytes to diseased tissues. Antagonists of CCR5 are believed to be of potential therapeutic value for the disorders mentioned above and HIV infection.
Gebhard, Thoma, François, Nuninger, Marc, Schaefer, Kayhan G, Akyel, Rainer, Albert, Christian, Beerli, Christian, Bruns, Eric, Francotte, Marcel, Luyten, Duncan, MacKenzie, Lukas, Oberer, Markus B, Streiff, Trixie, Wagner, Hansrudolf, Walter, Gisbert, Weckbecker, Hans-Guenter, Zerwes   +15 more
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Predicting Oral Absorption and Bioavailability

2003
Publisher Summary The prediction of oral absorption and bioavailability is an important tool, both in the early phases of drug discovery to select the most promising leads for further optimization and in the later stages to select candidates for clinical development.
Han, van de Waterbeemd, Barry C, Jones
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The Absolute Bioavailability of Oral Melatonin

The Journal of Clinical Pharmacology, 2000
The absolute bioavailability of oral melatonin tablets was studied in 12 normal healthy volunteers. Subjects were administered, in a randomized crossover fashion, melatonin 2 mg intravenously and 2 and 4 mg orally. Blood was sampled over approximately eight (estimated) half‐lives.
R L, DeMuro, A N, Nafziger, D E, Blask, A M, Menhinick, J S, Bertino   +4 more
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Oral bioavailability of clonidine in children

Pediatric Anesthesia, 2010
SummaryBackground: Oral clonidine is used as premedication in children. The bioavailability of clonidine given orally in adults is 75–100% but is unknown in children.Methods: Children (3–10 years) undergoing adenotonsillectomy were administered oral clonidine 4 mcg·kg−1mixed with apple fruit drink as premedication.
Peter, Larsson, Anders, Nordlinder, Henrik T G, Bergendahl, Per-Arne, Lönnqvist, Staffan, Eksborg, Nicole, Almenrader, Brian J, Anderson   +6 more
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Bioavailability of valsartan oral dosage forms

Clinical Pharmacology in Drug Development, 2013
AbstractThe oral bioavailability of valsartan from extemporaneous suspension and solution formulations were evaluated relative to tablet formulation in two separate open‐label, randomized crossover studies in healthy adults. In both studies, the plasma concentrations of valsartan after oral administration were analyzed using validated liquid ...
Gangadhar, Sunkara, Girish, Bende, Anisha E, Mendonza, Susan, Solar-Yohay, Shibadas, Biswal, Srikanth, Neelakantham, Robert, Wagner, Jimmy, Flarakos, Yiming, Zhang, Venkateswar, Jarugula   +9 more
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Oral bioavailability of high-dose metoclopramide

European Journal of Clinical Pharmacology, 1986
The oral bioavailability of high-dose metoclopramide was studied in 12 patients, who received oral or intravenous (i.v.) metoclopramide in random order with each of 2 consecutive courses of cytotoxic chemotherapy. The terminal half-life of metoclopramide was 7.1 +/- 0.4 h (mean +/- SEM) and was not affected by the route of drug administration.
W B, Taylor, D N, Bateman
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