Results 111 to 120 of about 587,078 (311)

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo‐Activatable Pyroptosis Inducer

Advanced Healthcare Materials, EarlyView.
This study presents alkylated nitrobenzoselenadiazole (NBSD) photosensitizers that self‐assemble into programmable aggregates, enabling photo‐triggered pyroptosis and enhanced ROS generation. The lead compound, NBSD‐NOc, exhibits superior photodynamic activity, high cellular uptake, and implantable gel compatibility with pH‐responsive release.
Jong Min An, Hyunyoung Choi, Hyo In Kim, Do‐Yeon Kim, Jahyun Kim, Jinbong Park, Junyang Jung, Na Young Jeong, Dokyoung Kim   +8 more
wiley   +1 more source

Machine learning combine with nomogram to guide the establishment of endoscopic assistant system for gasless transaxillary endoscopic thyroidectomy

Annals of Medicine
Objective To explore the influence related factors of endoscopic assistant in gasless transaxillary endoscopic thyroidectomy by using machine learning and nomogram, and construct an endoscopic assistant system.Methods A skilled endoscopic assistant(Group
Linjie Ma, Yuqiu Zhou, Chao Li, Xu Wang, Tong Liu   +4 more
doaj   +1 more source

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids

Advanced Healthcare Materials, EarlyView.
A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim, Seeun Kim, Dong Hyun Lee, Dae Hun Kim, Hye Bin Lee, Ye Seul Son, Mi‐Young Son, Soo Jin Oh, Ji‐Yoon Lee, Mi‐Ok Lee, Hyun Soo Cho, Dae‐Soo Kim, Cho‐Rok Jung, Hyun Mi Kang   +13 more
wiley   +1 more source

MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment

Bone Research
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as chronic local inflammation can largely impair bone healing.
Jiakang Yang, Jing Shuai, Lixuen Siow, Jingyi Lu, Miao Sun, Wenyue An, Mengfei Yu, Baixiang Wang, Qianming Chen   +8 more
doaj   +1 more source

Oral cancer

Western Journal of Medicine, 2001
C, Scully, S, Porter
openaire   +3 more sources

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Advanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale, Deborah Stanco, Roberta Visone, Bernd Stadlinger, Pierfrancesco Pagella, Marco Rasponi, Thimios A. Mitsiadis   +6 more
wiley   +1 more source

Early Diagnosis of Oral Cancer: The Erythroplastic Lesion in High Risk Sites [PDF]

, 1978
Arthur Mashberg, Lawrence Garfinkel
openalex   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source