Results 201 to 210 of about 587,078 (311)

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Immune Microenvironment in Oral Potentially Malignant Disorders and Oral Cancer: A Narrative Review. [PDF]

Int J Mol Sci
Ali A, Molska GR, Yeo H, Esfandiari N, Jeong W, Huang M, Magalhaes M.   +6 more
europepmc   +1 more source

Studies on Cell-mediated immune responses in oral cancer

, 1980
Atsushi SEYAMA, Keizo SUGIHARA, Hiromi Abe, Toshihiko SHIRATSUKI, Misao Yoneda, Koichi Hanada, Shoji OCHI, Koji YOSHIGA, Yasuo Takahashi, Kazuaki TAKADA   +9 more
openalex   +2 more sources

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Inhibition of TPI1 Sensitizes Cisplatin-Resistant Oral Cancer to Ferroptosis. [PDF]

Biomedicines
Wang D, Zheng H, Chen Y, Hao J, Zhou Y, Li N.   +5 more
europepmc   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Clinical outcomes and prognostic factors in multiple primary malignancies involving oral cancer. [PDF]

BMC Oral Health
Liu Q, Tang S, Yang L, Ou F, Li K, Lu H, Chen Z, Liao G, Liang Y.   +8 more
europepmc   +1 more source

A case of oral tuberculosis after treatment of cancer in the lower gingiva.

, 1985
Kazuhisa Iwata, Yoshiaki Komiya, Shohei Iwamoto, Akio Kobayashi   +3 more
openalex   +2 more sources

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Cannabis use disorder and five-year risk of oral cancer in a multicenter clinical cohort. [PDF]

Prev Med Rep
Cuomo RE.
europepmc   +1 more source