Results 91 to 100 of about 2,332,572 (294)

Mepolizumab for the management of chronic rhinosinusitis with nasal polyps across the United States: A retrospective study

Journal of Allergy and Clinical Immunology: Global
Background: Retrospective data are limited on the effectiveness of mepolizumab treatment that is reflective of real-world practice in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Juan Carlos Cardet, MD, MPH, Jared Silver, MD, Martin Maldonado-Puebla, MD, François Laliberté, MA, Chi Gao, PhD, Ramya Ramasubramanian, PhD, Annalise Hilts, BA, Kaixin Zhang, MSc, Jeremiah Hwee, PhD, Waseem Ahmed, MBA, Amy G. Edgecomb, PharmD, MPH   +10 more
doaj   +1 more source

Anterior Knee Unloader Brace Prescription Yields Moderate Compliance Rates and Improved Clinical Function in Patients with Patellofemoral Pain

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine clinical outcome changes and wear compliance rates associated with the use of a custom‐fit anterior knee unloader brace in a prospective cohort of patients with clinical symptoms derived from patellofemoral osteoarthritis (PFOA).
Andrew R. Phillips, Thomas Moran, Kofi K. Acheampong, Stephanie A. Boden, Erik C. Haneberg, William D. Bugbee, John P. Fulkerson, Simon Goertz, John G. Lane, Sabrina M. Strickland, Adam B. Yanke   +10 more
wiley   +1 more source

Perceptions of oral corticosteroid use for children with asthma in a survey of US caregivers

Frontiers in Pediatrics
IntroductionOral corticosteroids (OCS) are an essential component of asthma treatment, but their long-term effects can be serious and cumulative. Potentially serious effects include adrenal suppression and psychological effects. To mitigate side effects,
Nina C. Ramirez, Nina C. Ramirez, Vivian Hernandez-Trujillo, Vivian Hernandez-Trujillo, Kaharu Sumino, Dennis Williams, Mitu Patel, Donna D. Gardner   +7 more
doaj   +1 more source

Prescription Profile and Clinical Outcomes in Patients with Allergic Rhinitis Treated with Oral Antihistamines or Nasal Corticosteroids

International Archives of Otorhinolaryngology, 2019
Introduction Oral antihistamines and intranasal corticosteroids have been shown to be effective and safe for the treatment of allergic rhinitis; however, the evidence suggests a level of superiority of corticosteroids, so they should be preferred over ...
Guillermo Sánchez, Carlos Castro
doaj   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Excessive Short-acting Beta-agonists Prescriptions in COPD Treated with Triple Inhaler Therapy: A Possible Marker of Frequent Exacerbations. A Retrospective Cohort Study

Thoracic Research and Practice
OBJECTIVE: Short-acting β2-agonists (SABA) are used both in asthma and in chronic obstructive pulmonary disease (COPD); SABA use appears to be associated with an increased risk of exacerbations.
Bruno Sposato, Leonardo Gianluca Lacerenza, Elisa Petrucci, Alberto Ricci, Alberto Cresti, Pasquale Baratta, Andrea Serafini, Claudio Micheletto, Maurizio Di Tomassi, Antonio Perrella, Valerio Alonzi, Sara Croce, Marco Scalese   +12 more
doaj   +1 more source

Efficacy and Safety of Omalizumab Treatment Over a 16-Year Follow-Up: When a Clinical Trial Meets Real-Life

Journal of Asthma and Allergy, 2022
Francesco Menzella,1 Matteo Fontana,1 Marco Contoli,2 Patrizia Ruggiero,1 Carla Galeone,1 Silvia Capobelli,1 Anna Simonazzi,1 Chiara Catellani,1 Chiara Scelfo,1 Claudia Castagnetti,1 Francesco Livrieri,1 Nicola Facciolongo1 1Pulmonology Unit, Arcispedale
Menzella F, Fontana M, Contoli M, Ruggiero P, Galeone C, Capobelli S, Simonazzi A, Catellani C, Scelfo C, Castagnetti C, Livrieri F, Facciolongo N   +11 more
doaj  

Role of Corticosteroids in Oral Lesions [PDF]

, 2012
Glucocorticoids were first introduced in the 1940s and have become a widely prescribed class of drugs. Corticosteroids are a class of chemicals that includes steroid hormones naturally produced in the adrenal cortex of vertebrates and analogues of these hormones that are synthesized in laboratories.
Masoumeh Mehdipour, Ali Taghavi
openaire   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source