Results 71 to 80 of about 77,126 (264)

Systemic corticosteroid hypersensitivity in children [PDF]

, 2010
We describe 5 cases of immediate-type reactions to systemic corticosteroids observed during the last 2 decades in boys aged 2, 4, 8, 9, and 10 years.
Morais-Almeida, M, Santa Marta, C, Sousa, NG   +2 more
core  

Anti-IL5 Therapies for Severe Eosinophilic Asthma: Literature Review and Practical Insights

Journal of Asthma and Allergy, 2020
Francesco Menzella,1 Patrizia Ruggiero,1 Giulia Ghidoni,1 Matteo Fontana,1 Diego Bagnasco,2 Francesco Livrieri,1 Chiara Scelfo,1 Nicola Facciolongo1 1Pneumology Unit, Arcispedale Santa Maria Nuova, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia 42123,
Menzella F, Ruggiero P, Ghidoni G, Fontana M, Bagnasco D, Livrieri F, Scelfo C, Facciolongo N   +7 more
doaj  

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?

Drugs in Context, 2019
Severe refractory asthma is characterized by a higher risk of asthma-related symptoms, morbidities, and exacerbations. This disease also determines much greater healthcare costs and deterioration in health-related quality of life (HR-QoL).
Francesco Menzella, Mirella Biava, Diego Bagnasco, Carla Galeone, Anna Simonazzi, Patrizia Ruggiero, Nicola Facciolongo   +6 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Antiviral treatment for Bell's palsy (idiopathic facial paralysis) [PDF]

, 2009
BACKGROUND: Antiviral agents against herpes simplex virus are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but their effectiveness is uncertain. Significant morbidity can be associated with severe cases.
Abiko, Adour, Adour KK Swanson, Ahangar, Allen, Allen, Antunes, Aquino, Axelsson, Bateman, Brandenberg, Chen, Diego, Egger, Engström, Goudakos, Hato, Hato, Hernández, House, Hultcranzt, Ibarrondo, Inanli, Katusic, Kawaguchi, May, McCormick, Morgan, Morgenlander, Murakami, Petruzelli, Pietersen, Pietersen, Ramos Macias, Ross, Rowlands, Roy, Salinas, Sipe, Stjernquist-Desatnik, Sugita, Sullivan, Takasu, Theil, Wolf, Yanagihara, Yeo, Zhou   +47 more
core   +3 more sources

Short-term oral corticosteroid use and risk for major adverse cardiovascular events within one year in patients with chronic obstructive pulmonary disease, a Danish registry-based cohort study

European Clinical Respiratory Journal
Background Exacerbations of chronic obstructive pulmonary disease (COPD) often require treatment with oral corticosteroids (OCS). While OCS can improve forced expiratory volume in first second (FEV1) in the short term, there are still concerns about ...
Gertrud Baunsgaard-Pedersen, Barbara Bonnesen, Josefin Eklöf, Jens Ulrik Stæhr Jensen, Pradeesh Sivapalan   +4 more
doaj   +1 more source

Real-World Experience with Dupilumab in Severe Asthma: One-Year Data from an Italian Named Patient Program

Journal of Asthma and Allergy, 2021
Raffaele Campisi,1 Claudia Crimi,1 Santi Nolasco,2 Bianca Beghè,3 Leonardo Antonicelli,4 Gabriella Guarnieri,5 Nicola Scichilone,6 Morena Porto,2 Luigi Macchia,7 Giulia Scioscia,8 Maria Pia Foschino Barbaro,8 Alberto Papi,9 Nunzio Crimi1,2 ...
Campisi R, Crimi C, Nolasco S, Beghè B, Antonicelli L, Guarnieri G, Scichilone N, Porto M, Macchia L, Scioscia G, Foschino Barbaro MP, Papi A, Crimi N   +12 more
doaj  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease. [PDF]

, 2014
BACKGROUND: Inhaled corticosteroids (ICS) are anti-inflammatory drugs that have proven benefits for people with worsening symptoms of chronic obstructive pulmonary disease (COPD) and repeated exacerbations.
Agarwal, Allegra, Anderson, Anzueto, Bale, Blais, Bleecker, Bourbeau, Bourbeau, Briggs, Briggs, Briggs, British Thoracic Society, Burge, Burge, Burge, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Calverley, Cates, Celli, Celli, Celli, Celli, Celli, Celli, Chavannes, Choudhury, Choudhury, Cipriani, Corhay, D'Urzo, Dahl, Dal Negro, Dalal, DiSantostefano, Dransfield, Drummond, Effing, Egede, Ernst, Ferguson, Ferguson, Ferguson, Ferguson, Ferguson, Gizycki, Glenny, Grunsven, Grunsven, Halpin, Hanania, Hanania, Hanania, Hattotuwa, Horstman, Hunjan, Hunjan, Jarad, Jebrak, Jenkins, Jenkins, Johnell, Johnson, Jones, Jones, Jones, Jones, Jones, Jones, Kardos, Kardos, Keene, Korsgaard, Lacasse, Lange, Lapperre, Laptseva, Lofdahl, Lofdahl, Lofdahl, Lofdahl, Lofdahl, Lung Health Study Research Group, Mahler, Mahler, Marchand, Martinez, McDonough, McGarvey, Meer, Milanowski, Mirici, Monninkhof, Nannini, Nannini, Nitschmann, Ozol, Paggiaro, Partridge, Pauwels, Pauwels, Pauwels, Puhan, Renkema, Rennard, Roberts, Rossios, Sacchetta, Schermer, Senderovitz, Shaker, Shaker, Sharafkhaneh, Sharafkhaneh, Sin, Singanayagam, Singh, Song, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Spencer, Suissa, Szafranski, Tashkin, Valk, Valk, Verhoeven, Verhoeven, Verhoeven, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Vestbo, Weir, Wouters, Wouters, Yang, Yildiz   +163 more
core   +1 more source