Results 71 to 80 of about 2,984,423 (243)

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Sound effects : The oral/aural dimensions of literature in English Introduction [PDF]

, 2011
Sound Effects traces the history of the relationship between oral conditions and aural effect in English literature from its beginnings in the Anglo-Saxon period through to the twenty-first century. Few collections nowadays, other than textbook histories,
Rhodes, Neil, Jones, Chris
core   +2 more sources

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

Drug Delivery, 2017
Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration.
Lin Liu, WenDong Yao, YueFeng Rao, XiaoYang Lu, JianQing Gao   +4 more
doaj   +1 more source

Eudragit-Based Nanoparticles for Oral Drug Delivery

The development of oral drug delivery systems has become a major priority for pharmaceutical technology, driven by the growing demand for medicinal products that improve compliance, enhance therapeutic efficacy, and minimise drug-related adverse effects.
Filipa Bettencourt, Ana Cláudia Paiva-Santos, Francisco Veiga, Patrícia C. Pires, Amélia C. F. Vieira   +4 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Polymeric Nanoparticles as Oral and Intranasal Peptide Vaccine Delivery Systems: The Role of Shape and Conjugation

Vaccines
Mucosal vaccines are highly attractive due to high patient compliance and their suitability for mass immunizations. However, all currently licensed mucosal vaccines are composed of attenuated/inactive whole microbes, which are associated with a variety ...
Prashamsa Koirala, Ahmed O. Shalash, Sung-Po R. Chen, Mohammad O. Faruck, Jingwen Wang, Waleed M. Hussein, Zeinab G. Khalil, Robert J. Capon, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski   +10 more
doaj   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Surrogate‐Optimized Flow‐Guided Miniature Condenser for Rapid Exhaled Glucose Detection

Advanced Materials Technologies, EarlyView.
A surrogate‐optimized miniature condenser guides humid exhaled flow toward cold surfaces to accelerate exhaled breath condensate collection. By improving vapor access within a compact footprint, the design increases sample yield. This enables post‐collection enrichment and rapid colorimetric glucose detection from dilute exhaled biomarkers within a 5 ...
Yiming Thomas Lu, Yamin Mansur, Sai Peri, Jiangyuan Wan, Amio Pronoy Das Ritwik, Emily L. Johnson, Jingcheng Ma   +6 more
wiley   +1 more source