Results 91 to 100 of about 2,984,423 (243)

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Cryo-Milled β-Glucan Nanoparticles for Oral Drug Delivery

Gemcitabine is a nucleoside analog effective against a number of cancers. However, it has an oral bioavailability of less than 10%, due to its high hydrophilicity and low permeability through the intestinal epithelium.
Hongyu Li, Man Ying, Jingyuan Wen, Weiyue Lu, Guanyu Chen, Yi Liu, Darren Svirskis   +6 more
core   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Recent advances in the oral delivery of insulin

, 2014
Insulin was discovered over 90 years ago. However oral insulin still remains a challenging and elusive goal. Extensive efforts are being made worldwide for developing noninvasive drug delivery systems, mainly via oral route as it is the most widely ...
Rekha, MR, Sharma, CP
core   +1 more source

Zein-Based Nanocarriers: Advances in Oral Drug Delivery

Pharmaceutics
Oral administration remains the preferred drug delivery route but faces formidable gastrointestinal barriers, including enzymatic degradation, solubility limitations, and poor epithelial absorption.
Yuxin Liu, Dongyu An, Xiangjian Meng, Shiming Deng, Guijin Liu   +4 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Nutritional intervention based on curcumin-loaded polysaccharides nanoparticle for synergetic improvement of ulcerative colitis

Food Science and Human Wellness
The prevalence of ulcerative colitis (UC) is increasing annually, while current non-targeted drugs for UC have limited effectiveness, easily relapsed, and serious side effects.
Jun Yang, Jieqiong Lin, Yi Luo, Xianxiang Chen, Mingyue Shen, Yuanxing Wang, Jianhua Xie   +6 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

A Systematic Study on the Physicochemical Interactions Between Polymeric Micelles and Mucin: Toward the Development of Optimal Drug Delivery Nanocarriers

Advanced Materials Interfaces
The optimal performance of drug delivery formulations, including polymeric nanoparticles, relies on particle distribution throughout the body and the interactions with biological barriers, particularly mucosal layers, which often limit their potential. A
Matteo Tollemeto, Isidro Badillo‐Ramírez, Lasse Højlund Eklund Thamdrup, Yudong Li, Mahdi Ghavami, Tania Patiño Padial, Jørn B. Christensen, Jan vanHest, Anja Boisen   +8 more
doaj   +1 more source

Recent Advances in Drug Delivery from the Oral Cavity. Focus on innovative buccal drug delivery devices

, 2011
In this report, the drug administration via the oral cavity is discussed. Regional variations in oral mucosae, drug delivery via the keratinised mucosae for local treatment, and drug delivery via the not keratinised mucosae for local and systemic ...
PADERNI, Carlo, GIANNOLA, Libero Italo
core