Results 51 to 60 of about 1,813,651 (244)

Altered β-catenin expression in oral mucosal dysplasia: a comparative study

Journal of Applied Oral Science, 2015
Objective The current study aimed to investigate the β-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.Material and Methods Formalin-fixed, paraffin-embedded tissue samples of 39 OL (mild ...
Brunno Santos de Freitas SILVA, Caroline Alves de CASTRO, Sandra Lúcia Ventorin VON ZEIDLER, Suzana Cantanhede Orsini Machado de SOUSA, Aline Carvalho BATISTA, Fernanda Paula YAMAMOTO-SILVA   +5 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Histological grading of oral epithelial dysplasia: revisited [PDF]

The Journal of Pathology, 2001
Treatment of oral precancer is largely based on histological grading of epithelial dysplasia, despite the fact that this estimation is subjective and therefore carries a low reproducibility. The grade of epithelial dysplasia may not be proportional to the risk of malignant potential and clinical characteristics may complement therapeutic decisions ...
openaire   +2 more sources

Predicting Oral Cancer From Precursor Lesions: The Case for a Standardized Framework of Analysis to Improve Prediction Modeling

Head &Neck, EarlyView.
ABSTRACT Oral Cancer often occurs from the transformation of precursor lesions, and this offers an opportunity for early detection. Current methods to assess risk of precursor lesion progression to oral cancer incompletely predict risk. A multimodal framework that leverages machine learning is needed to improve prediction.
Michael E. Troka, James C. Gates
wiley   +1 more source

Expression of Epsin3 and its interaction with Notch signalling in oral epithelial dysplasia and oral squamous cell carcinoma [PDF]

, 2023
Background: Most oral squamous cell carcinoma patients present with late-stage disease. Early detection of the disease is considered to be the most effective way of improving patient outcomes. Several biomarkers have been identified as indicators of oral
Halah Ahmed, Paterson, Ian, Ruth A. Valentine, Marco Carrozzo, Cremona, Ottavio, Ahmed, Halah, Ian Paterson, Aziz, Sadat A, Carrozzo, Marco, Sadat A. Aziz, Robinson, Max, Ottavio Cremona, Max Robinson, Valentine, Ruth A   +13 more
core   +1 more source

Scattering attenuation microscopy of oral epithelial dysplasia

Journal of Biomedical Optics, 2010
We present a new method for quantitative visualization of premalignant oral epithelium called scattering attenuation microscopy (SAM). Using low-coherence interferometry, SAM projects measurements of epithelial optical attenuation onto an image of the tissue surface as a color map.
Tomlins, Pete H., Adegun, Oluyori, Hagi-Pavli, Eleni, Piper, Kim, Fortune, Farida, Bader, Dan   +5 more
openaire   +3 more sources

Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia

Molecular Cancer, 2007
Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known.
Hata Tsuyoshi, Deguchi Hiroyo, Wada Naoyuki, Ito Satoshi, Ishida Kosei, Hosoda Masaru, Nohno Tsutomu   +6 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Transformer-based Model for Oral Epithelial Dysplasia Segmentation

CoRR, 2023
Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. OED grading is subject to large inter/intra-rater variability, resulting in the under/over-treatment of patients. We developed a new Transformer-based pipeline to improve detection and segmentation of OED in haematoxylin and eosin (H&E)
Adam J. Shephard, Hanya Mahmood, Shan E Ahmed Raza, Anna Luíza Damaceno Araújo, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Kris D. McCombe, Stephanie G. Craig, Jacqueline A. James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram, Nasir M. Rajpoot   +14 more
openaire   +2 more sources

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand

BMC Oral Health, 2022
Background Lip and oral cavity cancer has been reported as the 10th most common cancer in Thailand. Recently, a screening program for oral potentially malignant disorders (OPMDs) and oral cancer was conducted in the northeastern Thailand which took into ...
Boworn Klongnoi, Vanvisa Sresumatchai, Harin Clypuing, Angkana Wisutthajaree, Jintana Pankam, Natchalee Srimaneekarn, Binit Shrestha, Siribang-on Piboonniyom Khovidhunkit   +7 more
doaj   +1 more source