Results 81 to 90 of about 1,813,651 (244)

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis

Journal of Pharmacy and Bioallied Sciences
Aim: Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis. Materials and Methods: The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded.
Mohammed Abidullah, Bushra Anjum, Shaikh Mohammed Imran Saudagar, Swathi Jahagirdar, Peddisetty Govind Raj Pankaj Mallik, Mediconda Shivaratna   +5 more
doaj   +1 more source

Radiographic Screening of Wild and Semi‐Wild Cape Ground Squirrels (Geosciurus inauris) for the Presence of Peri‐Apical Masses Associated With Elodont Incisor Teeth

Zoo Biology, EarlyView.
Peri‐apical masses were absent in both wild and semi‐wild Cape ground squirrels, despite dietary differences and minor incisor trauma. These findings suggest such lesions are rare outside captivity and not induced by low‐fiber diets alone, adding to the literature on environmental and dietary risk factors in elodont tooth pathology.
Quintin Norval, Adrian Tordiffe, Gerhard Steenkamp   +2 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma

European Journal of Oral Sciences, EarlyView.
Abstract Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti‐adhesion, and tumorigenesis.
Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap   +4 more
wiley   +1 more source

Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology. [PDF]

J Clin Med
Background: Oral epithelial dysplasia (OED) is considered one of the premalignant lesions for oral squamous cell carcinoma (OSCC), for which the five-year disease-free survival rate may vary widely.
Jerjes W, Hamdoon Z, Rashed D, Hopper C.
europepmc   +2 more sources

Predicting Malignant Transformation in Oral Epithelial Dysplasia: A Systematic Comparison of Artificial Intelligence‐Based Risk Models and Pathologist‐Based Microscopy

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background/Aims Risk prediction models (RPMs) based on histopathological analysis of oral epithelial dysplasia (OED) are increasingly used to stratify patients with oral potentially malignant disorders (OPMDs) and support personalized management.
Diele Carine Barreto Arantes, Lucas Monteiro Delgado, Marília de Marco Pinto Paiva dos Santos, Saman Warnakulasuriya, Marcelo Sperandio   +4 more
wiley   +1 more source

Immunohistochemical expression of SOX2 in oral normal epithelial, dysplasia and squamous cell carcinoma

Journal of Craniomaxillofacial Research, 2018
Objective: Oral squamous cell carcinoma (SCC) is an aggressive neoplasm with serious morbidity and mortality, which typically spreads through local invasive growth.
Pouria Motahhary, Mahnaz Sahebjamee, Maryam Nasimi, Zohreh Khodashenas, Fatemeh Hajian, Kambiz Kamyab   +5 more
doaj  

Correlation Between Prognostic Indicators, HPV Status, and Cancer Stem Cell Markers in a Population of Human Tongue Carcinomas

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is a significant public health issue. While tobacco and alcohol are established risk factors, the role of human papillomavirus (HPV) in oral carcinogenesis remains debated. Cancer stem cells (CSCs) are implicated in tumor aggressiveness and therapy resistance.
Adriely Primo da Silva, Beatriz Gomes Carreira Sartori, Carolina de Barros Gigliotti Vendramini, Adauto José Ferreira Nunes, Maria Renata Sales Nogueira   +4 more
wiley   +1 more source