Results 71 to 80 of about 1,433,667 (207)

Prevalence and associated factors of oral frailty in elderly patients undergoing elective surgery: a secondary analysis of a cross-sectional study

Frontiers in Medicine
BackgroundOral health has become a critical area of public health concern. Oral frailty refers to a significant decline in oral function and health, often manifested as impaired chewing and swallowing abilities as well as deterioration of oral structures.
Shizhao Wang, Keying Li, Yingchuan Zhang, Jiameng Yang, Rongtian Kang, Lining Huang, Lining Huang, Lining Huang   +7 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Physical Frailty and Oral Frailty Associated with Late-Life Depression in Community-Dwelling Older Adults

, 2022
Late-life depression is a major mental health problem and constitutes a heavy public health burden. Frailty, an aging-related syndrome, is reciprocally related to depressive symptoms.
Cheng-Wei Yen, Chien-Hung Lee, Shan-Shan Huang, Yuji Kabasawa, Ying-Chun Lin, Hsiao-Ling Huang   +5 more
core   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Frailty in survival analysis models (parametric frailty, parametric shared frailty, and frailty in Cox models [PDF]

Frailty models are used to model survival times in the presence of overdispersion or group-specific random effects. The latter are distinguished from the former by the term "shared" frailty models.
Roberto G. Gutierrez
core  

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Latent class analysis of oral frailty among community-dwelling older adults: functional profiles and associated factors

BMC Oral Health
Background Oral frailty, characterized by multidimensional declines in oral function, perception, and behavior, has emerged as an important concern in geriatric oral health. However, population heterogeneity in oral frailty among community-dwelling older
Yulian Li, Qian Zhu, Feng Zheng, Jialing Guo, Feifei Ai, Ga Zhuo   +5 more
doaj   +1 more source

Oral health literacy and oral frailty: a parallel mediation model of self-efficacy and health-related quality of life among older adult stroke patients

Frontiers in Public Health
ObjectivesThis study aims to investigate the relationship between oral health literacy and oral frailty, as well as the mediating effect of oral health self-efficacy and oral health-related quality of life among older adult stroke patients patients ...
Weiwei Yang, Zhenya Liu, Shijuan Gao, Huanyu Li, Guifang Zhang   +4 more
doaj   +1 more source

Meta-analysis of the Prevalence of Oral Frailty in the Elderly [PDF]

Zhongguo quanke yixue
Background Population aging has heightened, raising concerns about elderly health. Oral frailty, a novel frailty phenotype in the elderly, directly impacts the quality of life.
QIAO Wanwan, TIAN Haiping, JING Jie, GUO Runfang
doaj   +1 more source

Goodness-of-fit tests for the frailty distribution in proportional hazards models with shared frailty. [PDF]

Frailty models account for the clustering present in grouped event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. The choice of a
Claeskens, Gerda, Janssen, Paul, Geerdens, Candida   +2 more
core