Results 51 to 60 of about 1,433,667 (207)

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Cross-sectional study on oral frailty in elderly patients with periodontitis in Anhui

BMC Oral Health
Objective To investigate the status of oral frailty in elderly patients with periodontitis in Anhui province and analyze the influencing factors. Method Clinical data of elderly patients with periodontitis admitted to the Department of Periodontology and
Xin Xia, Haiyan Kong, Li Fan, Zhengyue Dai, Xueli Liu   +4 more
doaj   +1 more source

Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community

Frontiers in Aging Neuroscience
BackgroundCognitive function has been associated with both social and oral frailty. However, few studies have explored how social frailty and oral frailty jointly relate to cognitive function.
Zhiyue Jiang, Mei Wu, Ji Tang, Lingyao Xia, Jin Hu, Quanxiang Zhou, Xing Yang, Jingyuan Yang   +7 more
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Physical frailty intensifies the positive association of oral frailty with poor global cognitive function and executive function among older adults especially for females: a cross-sectional study

BMC Geriatrics
Background Oral frailty is reported to increase the risk of new onset of mild cognitive impairment. Whereas, the association of oral frailty with cognition among older adults in both physical frail and non-physical frail status has not been sufficiently ...
Yang Fei, Shuzhen Niu, Xueru Xi, Wenping Tang, Yue Zhao, Ge Zhang, Xiaohong Yu, Cheng Li, Xinru Li, Ying Liu, Yaxin Li, Yueheng Yin, Yan Cui, Xianwen Li   +13 more
doaj   +1 more source

Prevalence and associated factors with oral frailty in middle-aged and older hospitalized patients: a cross-sectional study

Frontiers in Public Health
BackgroundWith the development of the economy and society, people pay more and more attention to oral health. Oral frailty can limit nutritional intake and make an individual physically weak, which is detrimental to people’s health.
Jun-kai Dou, Huan Liu, Jiahui Min, Yang Luo, Qian Liu, Xue-zhi Shi, Xiubin Tao, Ming Zhang, Ming Zhang   +8 more
doaj   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

The symptom network of oral health conditions in older populations with oral frailty: a cross-sectional study

BMC Oral Health
Background Population aging is increasing globally, with oral frailty affecting 24% of the older population. Previous studies have demonstrated the relationship between oral frailty and poor oral health symptoms but the interactions and core symptoms ...
Zhang Chengrui, Xing Ying, Luan Wei, Chen Bin   +3 more
doaj   +1 more source

Oral frailty and its influencing factors among ICU patients with oral endotracheal intubation: a cross-sectional study

Frontiers in Medicine
ObjectiveTo investigate the level and factors associated with oral frailty among ICU patients with oral endotracheal intubation, and to provide references for the construction of targeted nursing intervention programs in the future.MethodsIn this single ...
Min Shi, Lei Li, Huaixiang Zhai
doaj   +1 more source

Functional Dentition, Chronic Periodontal Disease and Frailty in Older Adults—A Narrative Review

, 2022
Background: The likelihood of experiencing the impact of chronic disease rises with age, and cumulative functional deficits over time increase the risk of frailty in older adults.
Yan, Gabriel Lee Keng, Allen, Patrick Finbarr, Tan, Mei Na, Gabriel Lee Keng Yan, Chong Meng Tay, Mei Na Tan, Wong, Mun Loke, Mun Loke Wong, Patrick Finbarr Allen, Tay, Chong Meng   +9 more
core   +1 more source