Results 81 to 90 of about 11,814,383 (250)

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community

Frontiers in Aging Neuroscience
BackgroundCognitive function has been associated with both social and oral frailty. However, few studies have explored how social frailty and oral frailty jointly relate to cognitive function.
Zhiyue Jiang, Mei Wu, Ji Tang, Lingyao Xia, Jin Hu, Quanxiang Zhou, Xing Yang, Jingyuan Yang   +7 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Oral frailty and nutritional appetite in older adults: a cross-sectional, moderated mediation model of oral self-efficacy and personal mastery

BMC Oral Health
Background Oral frailty is significantly associated with poor appetite in older adults. While the underlying psychological mechanisms are thought to be universal, their expression can be shaped by local contexts.
Sichen Xia, Yuanyuan Wu, Qing Wang, Lei Wang, Xian Chen   +4 more
doaj   +1 more source

Impact of Oral Health Interventions on Sarcopenia and Frailty in Older Adults: A Systematic Review

Background/Objectives: Frailty and sarcopenia are geriatric syndromes associated with increased vulnerability to adverse health outcomes, including functional decline, disability, and mortality.
Bárbara Escobar, Fanny Petermann-Rocha, Benjamín Cáceres, Pilar Barahona, Andrés Celis, Erik Dreyer   +5 more
core   +1 more source

Laparoscopic Versus Open Surgery for Diverticular Disease: A Structured Review Across Clinical Settings and Operative Strategies

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Laparoscopic surgery is increasingly used to treat colonic diverticulitis; however, its role in emergency, perforated, high‐risk, and procedure‐specific settings remains uncertain. This structured narrative review evaluated and synthesized comparative evidence by clinical setting, operative strategy, and patient risk profile to provide a ...
Marie Hanaoka, Yudai Fukui, Koya Hida, Hiroya Takeuchi, Yusuke Kinugasa   +4 more
wiley   +1 more source

Investigating Eating Behaviors and Symptoms of Oral Frailty Using Questionnaires

, 2019
A questionnaire survey was conducted to investigate eating behavior and the subjective symptoms of oral frailty, and to examine the relationship between them. A total of 744 subjects with ages over 65 years were included.
Tsukasa Hihara, Tetsuo Ichikawa, Takaharu Goto   +2 more
core   +1 more source

Description of large, well‐preserved Enchodus specimens from the Bearpaw Formation of Alberta, Canada

The Anatomical Record, EarlyView.
Abstract Fishes of the genus Enchodus were abundant and cosmopolitan in the Late Cretaceous, but are primarily known from isolated remains in Canada. Four well‐preserved fish skulls were recovered in recent years from ammolite mines sampling the Bearpaw Formation of Southern Alberta, and are here referred to Enchodus petrosus Cope, 1874.
Luke E. Nelson, Alison M. Murray, Donald B. Brinkman   +2 more
wiley   +1 more source

Do malnutrition, sarcopenia and frailty overlap in nursing-home residents?

, 2020
Objectives: To study the prevalence and overlap between malnutrition, sarcopenia and frailty in a selected group of nursing home (NH) residents. Design Cross-sectional descriptive study. Setting: Nursing homes (NH). Participants: 92 residents taking part
Faxen-Irving, G.,, Boström, A-M, Franzen, E., Luiking, Y., Luiking, Y.,, Grönstedt, H.,, Vikström, S., Wimo, A., Boström, A-M,, Grönstedt, H., Seiger, Å.,, Faxen-Irving, G., Seiger, Å., Vikström, S.,, Cederholm, Tommy,, Cederholm, Tommy, Franzen, E.,, Wimo, A.,   +17 more
core   +1 more source