Results 151 to 160 of about 274,083 (217)

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Phytochemical Characterization of Freeze-Dried <i>Stenocereus stellatus</i> Seeds and Their Antihyperglycemic Activity in Experimental Prediabetes and Type 2 Diabetes. [PDF]

Molecules
Oidor-Chan VH, Díaz de León-Sánchez F, Valle-Mondragón LD, Martínez-Memije R, Torres-Narváez JC, Cruz-Sosa F, Patlán M, Miranda M, León-Martínez M, López-Olmos V, Ibarra-Lara L, Castrejón-Téllez V.   +11 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Hyperinsulinemic hypoglycemia in renal glucosuria in the presence of a novel sodium-glucose cotransporter 2 variant. [PDF]

JCEM Case Rep
Cadogan S, Madden A, O'Dwyer O, Kavanagh K, O'Byrne JJ, Byrne MM.   +5 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Influence of natural variations in eating rate and bolus properties on postprandial glucose and insulin responses in healthy adults. [PDF]

Eur J Nutr
Liu Z, van Bruinessen M, Heuven LAJ, Lasschuijt MP, Stieger M, Forde CG.   +5 more
europepmc   +1 more source

Association Between Periodontal Health and Perioperative Glycemic Outcomes in Diabetic Patients Undergoing Dental Procedures Under General Anesthesia: A Retrospective Cohort Study. [PDF]

Cureus
Negi P, Jangala TR, Karpe T, Kallala D, Betigeri A, Doshi MV.   +5 more
europepmc   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source