Results 21 to 30 of about 274,083 (217)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats

Chinese Journal of Physiology, 2019
Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo.
Rungchai Chaunchaiyakul, Naruemon Leelayuwat, Jin-Fu Wu, Chih-Yang Huang, Chia-Hua Kuo   +4 more
doaj   +1 more source

Predictive Value of Fasting Plasma Glucose on First Antenatal Visit before 20 Weeks of Gestation to Diagnose Gestational Diabetes Mellitus [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Gestational Diabetes Mellitus (GDM) is an important public health concern due to its association with adverse foetomaternal outcome. Steadily increasing prevalence necessitates screening and early treatment of women at risk of developing ...
Manisha Sharma, K Nayanisri, Rekha Jain, Rajiv Ranjan   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Role of positive glucose challenge test only versus oral glucose tolerance test in pregnancy outcome: a comparative study

Journal of Pathology of Nepal, 2019
Background: Gestational diabetes mellitus is defined as any degree of glucose intolerance which is first recognized during pregnancy and is associated with a number of adverse perinatal outcomes, such as neonatal hypoglycemia, macrosomia with an ...
Neha Homagai, Nirajan Mainali, Sikha Rijal   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Evaluation of patient satisfaction following oral glucose tolerance test

Northwestern Medical Journal
Aim: Diabetes mellitus (DM) is a common metabolic disease. Early diagnosis of diabetes prevents the increase in mortality and morbidity due to complications.
Püren Gökbulut, Habib Bilen, Emin Murat Akbaş, Çigdem Özdemir, Volkan Gökbulut, Gönül Koç   +5 more
doaj   +1 more source

Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals

Endocrinology, Diabetes & Metabolism, 2020
Aims This study aims to assess insulin secretion and resistance through oral glucose tolerance test (OGTT) among young Japanese individuals. Subjects and methods We enrolled 595 young healthy Japanese individuals aged 22‐29 years. They underwent an OGTT,
Hirotaka Ishigaki, Akihiro Yoshida, Osamu Araki, Takao Kimura, Katsuhiko Tsunekawa, Yoshifumi Shoho, Makoto Nara, Tomoyuki Aoki, Takayuki Ogiwara, Masami Murakami   +9 more
doaj   +1 more source

Acromegaly with initial negative oral glucose tolerance test: a case report

Journal of Medical Case Reports, 2023
Background Acromegaly can be diagnosed by a growth hormone value ≥ 1 µg/L following an oral glucose tolerance test. However, normal growth hormone suppression following oral glucose tolerance test may not exclude acromegaly.
Wen-Hsuan Tsai, Ming-Nan Chien, Shuen-Han Dai, Yun-Kai Chan   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source