Results 21 to 30 of about 36,741 (290)

Safety and efficacy of gliclazide as treatment for type 2 diabetes: a systematic review and meta-analysis of randomized trials.

PLoS ONE, 2014
Objective and designGliclazide has been associated with a low risk of hypoglycemic episodes and beneficial long-term cardiovascular safety in observational cohorts.
Gijs W D Landman, Geertruide H de Bock, Kornelis J J van Hateren, Peter R van Dijk, Klaas H Groenier, Rijk O B Gans, Sebastiaan T Houweling, Henk J G Bilo, Nanne Kleefstra   +8 more
doaj   +1 more source

Assessment of Type 2 Diabetes Patients’ Knowledge of Oral Hypoglycemic Agents

Journal of Health Science and Medical Research (JHSMR), 2020
Objective: Considering that adherence level affects diabetes treatment success and maintenance of glycemic control greatly, the aim of this study was to examine diabetes patients’ adherence to oral hypoglycemic agents (OHAs) and knowledge about their ...
Milica Paut Kusturica, Mina Maričić, Ana Tomas Petrović, Tihomir Dugandžija, Veljko Crnobrnja, Olga Horvat   +5 more
doaj   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Clinical and biochemical profile of lean type 2 diabetes mellitus

Indian Journal of Endocrinology and Metabolism, 2011
Background: Type 2 diabetes mellitus is the most prevalent form of diabetes worldwide. In western countries majority of the cases are obese. The scenario may be different in certain parts of India.
Punyakrit Deb Barma, Salam Ranabir, Lallan Prasad, Thangjam Premchand Singh   +3 more
doaj   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Safety, Efficacy, and Bioavailability of Fixed-Dose Combinations in Type 2 Diabetes Mellitus: A Systematic Updated Review

Current Therapeutic Research, 2017
Purpose: Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance. As time progresses, monotherapy often does not provide effective glycemic control, generating the need for an add-on therapy.
Thangavel Mahalingam Vijayakumar, M.Pharm, PhD, Jayasutha Jayram, M.Pharm, Vishnu Meghana Cheekireddy, Pharm.D, Dasari Himaja, Pharm.D, Yalamanchili Dharma Teja, Pharm.D, Damodharan Narayanasamy, M.Pharm, PhD   +5 more
doaj   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +3 more
wiley   +1 more source

Adherence to Oral Hypoglycemic Agents in Hawaii

Preventing Chronic Disease, 2005
Introduction Adherence to oral hypoglycemic agents is essential to reducing the poor health outcomes of populations at high risk for developing diabetes and its chronic complications. The goal of this study was to identify characteristics of patients in
Deborah A. Taira, ScD, Rachel Lee
doaj